Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay
In recent months, Paraguay has been grappled with a notable monkeypox outbreak, straining its healthcare infrastructure. The sudden spike in cases underlines the imperative need for a comprehensive understanding of the virus’s dynamics, enabling the formulation of robust containment measures. To add...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/16/1/83 |
| _version_ | 1827371031620222976 |
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| author | Cynthia Vazquez Vagner Fonseca Andrea Gomez de la Fuente Sandra Gonzalez Fatima Fleitas Mauricio Lima Natália R. Guimarães Felipe C. M. Iani Analia Rojas Tania Alfonso Cesar Cantero Julio Barrios Shirley Villalba Maria Jose Ortega Juan Torales Maria Liz Gamarra Carolina Aquino Leticia Franco Jairo Mendez Rico Luiz Carlos Junior Alcantara Marta Giovanetti |
| author_facet | Cynthia Vazquez Vagner Fonseca Andrea Gomez de la Fuente Sandra Gonzalez Fatima Fleitas Mauricio Lima Natália R. Guimarães Felipe C. M. Iani Analia Rojas Tania Alfonso Cesar Cantero Julio Barrios Shirley Villalba Maria Jose Ortega Juan Torales Maria Liz Gamarra Carolina Aquino Leticia Franco Jairo Mendez Rico Luiz Carlos Junior Alcantara Marta Giovanetti |
| author_sort | Cynthia Vazquez |
| collection | DOAJ |
| description | In recent months, Paraguay has been grappled with a notable monkeypox outbreak, straining its healthcare infrastructure. The sudden spike in cases underlines the imperative need for a comprehensive understanding of the virus’s dynamics, enabling the formulation of robust containment measures. To address this challenge, our team joined forces with the Central Public Health Laboratory of Asunción and the Pan-American Health Organization. Through this collaboration, we employed portable whole-genome sequencing combined with phylodynamic analysis to examine the MPXV strains circulating in Paraguay. Our genomic monitoring approach has produced the first 30 whole-genome sequences from Paraguay, all of which were identified under lineage IIb. Interestingly, our data suggest that the origin of the monkeypox virus in Paraguay at the beginning of 2022 can be traced back to Brazil. This introduction subsequently catalyzed further community spread that was further exacerbated by several independent introduction events as time progressed. These findings not only shed light on the transmission patterns of the virus but also highlight the pivotal role such insights play in sculpting effective response strategies and driving impactful public health measures. Furthermore, our findings strongly advocate intensified surveillance at international borders, ensuring swift detection and proactive countermeasures against potential outbreaks in the future. |
| first_indexed | 2024-03-08T10:32:15Z |
| format | Article |
| id | doaj.art-2fad9ada272047d8bb82d284d5783087 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T10:32:15Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-2fad9ada272047d8bb82d284d57830872024-01-26T18:48:05ZengMDPI AGViruses1999-49152024-01-011618310.3390/v16010083Exploring the Genomic Dynamics of the Monkeypox Epidemic in ParaguayCynthia Vazquez0Vagner Fonseca1Andrea Gomez de la Fuente2Sandra Gonzalez3Fatima Fleitas4Mauricio Lima5Natália R. Guimarães6Felipe C. M. Iani7Analia Rojas8Tania Alfonso9Cesar Cantero10Julio Barrios11Shirley Villalba12Maria Jose Ortega13Juan Torales14Maria Liz Gamarra15Carolina Aquino16Leticia Franco17Jairo Mendez Rico18Luiz Carlos Junior Alcantara19Marta Giovanetti20Laboratorio Central de Salud Pública, Asunción 001535, ParaguayCoordenação de Vigilância, Preparação e Resposta à Emergências e Desastres (PHE), Organização Pan-Americana da Saúde/Organização Mundial da Saúde (OPAS/OMS), Brasilia 70312-970, BrazilLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, BrazilLaboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, BrazilLaboratorio Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte 30510-010, BrazilLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayLaboratorio Central de Salud Pública, Asunción 001535, ParaguayInfectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organization/World Health Organization (PAHO/WHO), Washington, DC 20037, USAInfectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organization/World Health Organization (PAHO/WHO), Washington, DC 20037, USAInstituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-002, BrazilClimate Amplified Diseases and Epidemics (CLIMADE), University of Washington, Seattle, WA 98195, USAIn recent months, Paraguay has been grappled with a notable monkeypox outbreak, straining its healthcare infrastructure. The sudden spike in cases underlines the imperative need for a comprehensive understanding of the virus’s dynamics, enabling the formulation of robust containment measures. To address this challenge, our team joined forces with the Central Public Health Laboratory of Asunción and the Pan-American Health Organization. Through this collaboration, we employed portable whole-genome sequencing combined with phylodynamic analysis to examine the MPXV strains circulating in Paraguay. Our genomic monitoring approach has produced the first 30 whole-genome sequences from Paraguay, all of which were identified under lineage IIb. Interestingly, our data suggest that the origin of the monkeypox virus in Paraguay at the beginning of 2022 can be traced back to Brazil. This introduction subsequently catalyzed further community spread that was further exacerbated by several independent introduction events as time progressed. These findings not only shed light on the transmission patterns of the virus but also highlight the pivotal role such insights play in sculpting effective response strategies and driving impactful public health measures. Furthermore, our findings strongly advocate intensified surveillance at international borders, ensuring swift detection and proactive countermeasures against potential outbreaks in the future.https://www.mdpi.com/1999-4915/16/1/83monkeypox virusmpoxgenomic surveillanceParaguay |
| spellingShingle | Cynthia Vazquez Vagner Fonseca Andrea Gomez de la Fuente Sandra Gonzalez Fatima Fleitas Mauricio Lima Natália R. Guimarães Felipe C. M. Iani Analia Rojas Tania Alfonso Cesar Cantero Julio Barrios Shirley Villalba Maria Jose Ortega Juan Torales Maria Liz Gamarra Carolina Aquino Leticia Franco Jairo Mendez Rico Luiz Carlos Junior Alcantara Marta Giovanetti Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay Viruses monkeypox virus mpox genomic surveillance Paraguay |
| title | Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay |
| title_full | Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay |
| title_fullStr | Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay |
| title_full_unstemmed | Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay |
| title_short | Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay |
| title_sort | exploring the genomic dynamics of the monkeypox epidemic in paraguay |
| topic | monkeypox virus mpox genomic surveillance Paraguay |
| url | https://www.mdpi.com/1999-4915/16/1/83 |
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