Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI
Background: Inherent to its geometry, echocardiographic imaging of the systemic right ventricle (RV) is challenging. Therefore, echocardiographic assessment of systemic RV function may not always be feasible and/or reproducible in daily practice. Here, we aim to validate the usefulness of a comprehe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.644193/full |
| _version_ | 1818910354681364480 |
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| author | Tjitske E. Zandstra Monique R. M. Jongbloed Monique R. M. Jongbloed Ralph L. Widya Arend D. J. ten Harkel Eduard R. Holman Bart J. A. Mertens Hubert W. Vliegen Anastasia D. Egorova Martin J. Schalij Philippine Kiès |
| author_facet | Tjitske E. Zandstra Monique R. M. Jongbloed Monique R. M. Jongbloed Ralph L. Widya Arend D. J. ten Harkel Eduard R. Holman Bart J. A. Mertens Hubert W. Vliegen Anastasia D. Egorova Martin J. Schalij Philippine Kiès |
| author_sort | Tjitske E. Zandstra |
| collection | DOAJ |
| description | Background: Inherent to its geometry, echocardiographic imaging of the systemic right ventricle (RV) is challenging. Therefore, echocardiographic assessment of systemic RV function may not always be feasible and/or reproducible in daily practice. Here, we aim to validate the usefulness of a comprehensive range of 32 echocardiographic measurements of systemic RV function in a longitudinal cohort by serial assessment of their correlations with cardiac magnetic resonance (CMR)-derived systemic RV ejection fraction (RVEF).Methods: A single-center, retrospective cohort study was performed. Adult patients with a systemic RV who underwent a combination of both CMR and echocardiography at two different points in time were included. Off-line analysis of echocardiographic images was blinded to off-line CMR analysis and vice versa. In half of the echocardiograms, measurements were repeated by a second observer blinded to the results of the first. Correlations between echocardiographic and CMR measures were assessed with Pearson's correlation coefficient and interobserver agreement was quantified with intraclass correlation coefficients (ICC).Results: Fourteen patients were included, of which 4 had congenitally corrected transposition of the great arteries (ccTGA) and 10 patients had TGA late after an atrial switch operation. Eight patients (57%) were female. There was a mean of 8 years between the first and second imaging assessment. Only global systemic RV function, fractional area change (FAC), and global longitudinal strain (GLS) were consistently, i.e., at both time points, correlated with CMR-RVEF (global RV function: r = −0.77/r = −0.63; FAC: r = 0.79/r = 0.67; GLS: r = −0.73/r = −0.70, all p-values < 0.05). The ICC of GLS (0.82 at t = 1, p = 0.006, 0.77 at t = 2, p = 0.024) was higher than the ICC of FAC (0.35 at t = 1, p = 0.196, 0.70 at t = 2, p = 0.051) at both time points.Conclusion: GLS appears to be the most robust echocardiographic measurement of systemic RV function with good correlation with CMR-RVEF and reproducibility. |
| first_indexed | 2024-12-19T22:41:29Z |
| format | Article |
| id | doaj.art-2fae2090e3924377b7cac6c4620b4c89 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-19T22:41:29Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-2fae2090e3924377b7cac6c4620b4c892022-12-21T20:03:03ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-03-01810.3389/fcvm.2021.644193644193Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRITjitske E. Zandstra0Monique R. M. Jongbloed1Monique R. M. Jongbloed2Ralph L. Widya3Arend D. J. ten Harkel4Eduard R. Holman5Bart J. A. Mertens6Hubert W. Vliegen7Anastasia D. Egorova8Martin J. Schalij9Philippine Kiès10Department of Cardiology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Cardiology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Anatomy and Embryology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Paediatrics, Leiden University Medical Center, Leiden, NetherlandsDepartment of Cardiology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, NetherlandsDepartment of Cardiology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Cardiology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Cardiology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Cardiology, Leiden University Medical Center, Leiden, NetherlandsBackground: Inherent to its geometry, echocardiographic imaging of the systemic right ventricle (RV) is challenging. Therefore, echocardiographic assessment of systemic RV function may not always be feasible and/or reproducible in daily practice. Here, we aim to validate the usefulness of a comprehensive range of 32 echocardiographic measurements of systemic RV function in a longitudinal cohort by serial assessment of their correlations with cardiac magnetic resonance (CMR)-derived systemic RV ejection fraction (RVEF).Methods: A single-center, retrospective cohort study was performed. Adult patients with a systemic RV who underwent a combination of both CMR and echocardiography at two different points in time were included. Off-line analysis of echocardiographic images was blinded to off-line CMR analysis and vice versa. In half of the echocardiograms, measurements were repeated by a second observer blinded to the results of the first. Correlations between echocardiographic and CMR measures were assessed with Pearson's correlation coefficient and interobserver agreement was quantified with intraclass correlation coefficients (ICC).Results: Fourteen patients were included, of which 4 had congenitally corrected transposition of the great arteries (ccTGA) and 10 patients had TGA late after an atrial switch operation. Eight patients (57%) were female. There was a mean of 8 years between the first and second imaging assessment. Only global systemic RV function, fractional area change (FAC), and global longitudinal strain (GLS) were consistently, i.e., at both time points, correlated with CMR-RVEF (global RV function: r = −0.77/r = −0.63; FAC: r = 0.79/r = 0.67; GLS: r = −0.73/r = −0.70, all p-values < 0.05). The ICC of GLS (0.82 at t = 1, p = 0.006, 0.77 at t = 2, p = 0.024) was higher than the ICC of FAC (0.35 at t = 1, p = 0.196, 0.70 at t = 2, p = 0.051) at both time points.Conclusion: GLS appears to be the most robust echocardiographic measurement of systemic RV function with good correlation with CMR-RVEF and reproducibility.https://www.frontiersin.org/articles/10.3389/fcvm.2021.644193/fullechocardiographymagnetic resonance imagingtransposition of great vesselsobserver variationcongenital heart disease |
| spellingShingle | Tjitske E. Zandstra Monique R. M. Jongbloed Monique R. M. Jongbloed Ralph L. Widya Arend D. J. ten Harkel Eduard R. Holman Bart J. A. Mertens Hubert W. Vliegen Anastasia D. Egorova Martin J. Schalij Philippine Kiès Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI Frontiers in Cardiovascular Medicine echocardiography magnetic resonance imaging transposition of great vessels observer variation congenital heart disease |
| title | Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI |
| title_full | Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI |
| title_fullStr | Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI |
| title_full_unstemmed | Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI |
| title_short | Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI |
| title_sort | validation and feasibility of echocardiographic assessment of systemic right ventricular function serial correlation with mri |
| topic | echocardiography magnetic resonance imaging transposition of great vessels observer variation congenital heart disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.644193/full |
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