Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review
Postoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/2/98 |
| _version_ | 1797620867159556096 |
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| author | Jie Cai Jiaming Guo Shige Wang |
| author_facet | Jie Cai Jiaming Guo Shige Wang |
| author_sort | Jie Cai |
| collection | DOAJ |
| description | Postoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to be further studied. In addition, few current treatments are consistently effective in the prevention of postoperative adhesion. Hydrogel is a kind of water-expanding crosslinked hydrophilic polymer network generated by a simple reaction of one or more monomers. Due to the porous structure, hydrogels can load different drugs and control the drug release kinetics. Evidence from existing studies has confirmed the feasibility and superiority of using hydrogels to counter postoperative adhesions, primarily due to their outstanding antifouling ability. In this review, the current research status of hydrogels as anti-adhesion barriers is summarized, the character of hydrogels in the prevention of postoperative adhesion is briefly introduced, and future research directions are discussed. |
| first_indexed | 2024-03-11T08:47:40Z |
| format | Article |
| id | doaj.art-2fafac1516654087b88d64488a87f4fb |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T08:47:40Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-2fafac1516654087b88d64488a87f4fb2023-11-16T20:39:11ZengMDPI AGGels2310-28612023-01-01929810.3390/gels9020098Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A ReviewJie Cai0Jiaming Guo1Shige Wang2School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, ChinaDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, No. 800 Xiangyin Road, Shanghai 200433, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, ChinaPostoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to be further studied. In addition, few current treatments are consistently effective in the prevention of postoperative adhesion. Hydrogel is a kind of water-expanding crosslinked hydrophilic polymer network generated by a simple reaction of one or more monomers. Due to the porous structure, hydrogels can load different drugs and control the drug release kinetics. Evidence from existing studies has confirmed the feasibility and superiority of using hydrogels to counter postoperative adhesions, primarily due to their outstanding antifouling ability. In this review, the current research status of hydrogels as anti-adhesion barriers is summarized, the character of hydrogels in the prevention of postoperative adhesion is briefly introduced, and future research directions are discussed.https://www.mdpi.com/2310-2861/9/2/98hydrogelpostoperative adhesionbiocompatibilitybiodegradabilitydrug delivery |
| spellingShingle | Jie Cai Jiaming Guo Shige Wang Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review Gels hydrogel postoperative adhesion biocompatibility biodegradability drug delivery |
| title | Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review |
| title_full | Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review |
| title_fullStr | Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review |
| title_full_unstemmed | Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review |
| title_short | Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review |
| title_sort | application of polymer hydrogels in the prevention of postoperative adhesion a review |
| topic | hydrogel postoperative adhesion biocompatibility biodegradability drug delivery |
| url | https://www.mdpi.com/2310-2861/9/2/98 |
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