Activation of TGF-β1/α-SMA/Col I Profibrotic Pathway in Fibroblasts by Galectin-3 Contributes to Atrial Fibrosis in Experimental Models and Patients

Activation of TGF-β1/α-SMA/Col I Profibrotic Pathway in Fibroblasts by Galectin-3 Contributes to Atrial Fibrosis in Experimental Models and Patients

Background/Aims: This study aimed to evaluate whether galectin-3 (Gal-3) contributes actively to atrial fibrosis both in patients and experimental atrial fibrillation (AF) models. Methods: Mouse HL-1 cardiomyocytes were subjected to rapid electrical stimulation (RES) to explore Gal-3 expression and...

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Bibliographic Details
Main Authors: Hua Shen, Jing Wang, Jie Min, Wang Xi, Yang Gao, Liang Yin, Yue Yu, Kai Liu, Jian Xiao, Yu-feng Zhang, Zhi-nong Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Atrial fibrillation
Fibrosis
Galectin-3
HL-1 cell
Rapid atrial pacing
Online Access:https://www.karger.com/Article/FullText/490077

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