Signatures of selection in the genome of Swedish warmblood horses selected for sport performance
Abstract Background A growing demand for improved physical skills and mental attitude in modern sport horses has led to strong selection for performance in many warmblood studbooks. The aim of this study was to detect genomic regions with low diversity, and therefore potentially under selection, in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Genomics |
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| Online Access: | http://link.springer.com/article/10.1186/s12864-019-6079-1 |
| _version_ | 1818514919156350976 |
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| author | Michela Ablondi Åsa Viklund Gabriella Lindgren Susanne Eriksson Sofia Mikko |
| author_facet | Michela Ablondi Åsa Viklund Gabriella Lindgren Susanne Eriksson Sofia Mikko |
| author_sort | Michela Ablondi |
| collection | DOAJ |
| description | Abstract Background A growing demand for improved physical skills and mental attitude in modern sport horses has led to strong selection for performance in many warmblood studbooks. The aim of this study was to detect genomic regions with low diversity, and therefore potentially under selection, in Swedish Warmblood horses (SWB) by analysing high-density SNP data. To investigate if such signatures could be the result of selection for equestrian sport performance, we compared our SWB SNP data with those from Exmoor ponies, a horse breed not selected for sport performance traits. Results The genomic scan for homozygous regions identified long runs of homozygosity (ROH) shared by more than 85% of the genotyped SWB individuals. Such ROH were located on ECA4, ECA6, ECA7, ECA10 and ECA17. Long ROH were instead distributed evenly across the genome of Exmoor ponies in 77% of the chromosomes. Two population differentiation tests (FST and XP-EHH) revealed signatures of selection on ECA1, ECA4, and ECA6 in SWB horses. Conclusions Genes related to behaviour, physical abilities and fertility, appear to be targets of selection in the SWB breed. This study provides a genome-wide map of selection signatures in SWB horses, and ground for further functional studies to unravel the biological mechanisms behind complex traits in horses. |
| first_indexed | 2024-12-11T00:22:15Z |
| format | Article |
| id | doaj.art-2fb297d47b8a4e8b904247ac5cdd7f4c |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-11T00:22:15Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-2fb297d47b8a4e8b904247ac5cdd7f4c2022-12-22T01:27:41ZengBMCBMC Genomics1471-21642019-09-0120111210.1186/s12864-019-6079-1Signatures of selection in the genome of Swedish warmblood horses selected for sport performanceMichela Ablondi0Åsa Viklund1Gabriella Lindgren2Susanne Eriksson3Sofia Mikko4Dept. of Animal Breeding and Genetics, Swedish University of Agricultural SciencesDept. of Animal Breeding and Genetics, Swedish University of Agricultural SciencesDept. of Animal Breeding and Genetics, Swedish University of Agricultural SciencesDept. of Animal Breeding and Genetics, Swedish University of Agricultural SciencesDept. of Animal Breeding and Genetics, Swedish University of Agricultural SciencesAbstract Background A growing demand for improved physical skills and mental attitude in modern sport horses has led to strong selection for performance in many warmblood studbooks. The aim of this study was to detect genomic regions with low diversity, and therefore potentially under selection, in Swedish Warmblood horses (SWB) by analysing high-density SNP data. To investigate if such signatures could be the result of selection for equestrian sport performance, we compared our SWB SNP data with those from Exmoor ponies, a horse breed not selected for sport performance traits. Results The genomic scan for homozygous regions identified long runs of homozygosity (ROH) shared by more than 85% of the genotyped SWB individuals. Such ROH were located on ECA4, ECA6, ECA7, ECA10 and ECA17. Long ROH were instead distributed evenly across the genome of Exmoor ponies in 77% of the chromosomes. Two population differentiation tests (FST and XP-EHH) revealed signatures of selection on ECA1, ECA4, and ECA6 in SWB horses. Conclusions Genes related to behaviour, physical abilities and fertility, appear to be targets of selection in the SWB breed. This study provides a genome-wide map of selection signatures in SWB horses, and ground for further functional studies to unravel the biological mechanisms behind complex traits in horses.http://link.springer.com/article/10.1186/s12864-019-6079-1Haplotype homozygosityHorsePerformanceRuns of homozygositySelection signature |
| spellingShingle | Michela Ablondi Åsa Viklund Gabriella Lindgren Susanne Eriksson Sofia Mikko Signatures of selection in the genome of Swedish warmblood horses selected for sport performance BMC Genomics Haplotype homozygosity Horse Performance Runs of homozygosity Selection signature |
| title | Signatures of selection in the genome of Swedish warmblood horses selected for sport performance |
| title_full | Signatures of selection in the genome of Swedish warmblood horses selected for sport performance |
| title_fullStr | Signatures of selection in the genome of Swedish warmblood horses selected for sport performance |
| title_full_unstemmed | Signatures of selection in the genome of Swedish warmblood horses selected for sport performance |
| title_short | Signatures of selection in the genome of Swedish warmblood horses selected for sport performance |
| title_sort | signatures of selection in the genome of swedish warmblood horses selected for sport performance |
| topic | Haplotype homozygosity Horse Performance Runs of homozygosity Selection signature |
| url | http://link.springer.com/article/10.1186/s12864-019-6079-1 |
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