Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers
Kaposi sarcoma (KS) is the most frequent AIDS-defining cancer worldwide. Kaposi sarcoma associated herpesvirus (KSHV) is the etiological agent of KS, and the virus is also associated with two lymphoproliferative diseases. Both KS and KSHV-associated lymphomas, are cancers of unique molecular compos...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-04-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00141/full |
| _version_ | 1818984917476835328 |
|---|---|
| author | Dirk P Dittmer Kristy L Richards Blossom eDamania |
| author_facet | Dirk P Dittmer Kristy L Richards Blossom eDamania |
| author_sort | Dirk P Dittmer |
| collection | DOAJ |
| description | Kaposi sarcoma (KS) is the most frequent AIDS-defining cancer worldwide. Kaposi sarcoma associated herpesvirus (KSHV) is the etiological agent of KS, and the virus is also associated with two lymphoproliferative diseases. Both KS and KSHV-associated lymphomas, are cancers of unique molecular composition. They represent a challenge for cancer treatment and an opportunity to identify new mechanisms of transformation. Here, we review the current clinical insights into KSHV-associated cancers and discuss scientific insights into the pathobiology of KS, primary effusion lymphoma and multicentric Castleman’s disease. |
| first_indexed | 2024-12-20T18:26:37Z |
| format | Article |
| id | doaj.art-2fb45d75cac241059b8203f0931e90f3 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T18:26:37Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-2fb45d75cac241059b8203f0931e90f32022-12-21T19:30:07ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2012-04-01310.3389/fmicb.2012.0014122636Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancersDirk P Dittmer0Kristy L Richards1Blossom eDamania2University of North Carolina at Chapel HillUniversity of North Carolina at Chapel HillUniversity of North Carolina at Chapel HillKaposi sarcoma (KS) is the most frequent AIDS-defining cancer worldwide. Kaposi sarcoma associated herpesvirus (KSHV) is the etiological agent of KS, and the virus is also associated with two lymphoproliferative diseases. Both KS and KSHV-associated lymphomas, are cancers of unique molecular composition. They represent a challenge for cancer treatment and an opportunity to identify new mechanisms of transformation. Here, we review the current clinical insights into KSHV-associated cancers and discuss scientific insights into the pathobiology of KS, primary effusion lymphoma and multicentric Castleman’s disease.http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00141/fullLymphomaSarcomaKSHVtherapyviral cancer |
| spellingShingle | Dirk P Dittmer Kristy L Richards Blossom eDamania Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers Frontiers in Microbiology Lymphoma Sarcoma KSHV therapy viral cancer |
| title | Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers |
| title_full | Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers |
| title_fullStr | Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers |
| title_full_unstemmed | Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers |
| title_short | Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers |
| title_sort | treatment of kaposi sarcoma associated herpesvirus kshv associated cancers |
| topic | Lymphoma Sarcoma KSHV therapy viral cancer |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00141/full |
| work_keys_str_mv | AT dirkpdittmer treatmentofkaposisarcomaassociatedherpesviruskshvassociatedcancers AT kristylrichards treatmentofkaposisarcomaassociatedherpesviruskshvassociatedcancers AT blossomedamania treatmentofkaposisarcomaassociatedherpesviruskshvassociatedcancers |