Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study
Abstract Background Schizophrenia is associated with multiple neurotransmitter disorders, including serotonin (5-hydroxytryptamine, 5-HT). The neuromodulatory action of serotonin on brain function largely depends on the action of specific subtypes of serotonin receptors. The serotonin receptor 1B (H...
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| Language: | English |
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BMC
2018-09-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-018-1849-x |
| _version_ | 1819113827474604032 |
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| author | Xi Xia Mei Ding Jin-feng Xuan Jia-xin Xing Hao Pang Bao-jie Wang Jun Yao |
| author_facet | Xi Xia Mei Ding Jin-feng Xuan Jia-xin Xing Hao Pang Bao-jie Wang Jun Yao |
| author_sort | Xi Xia |
| collection | DOAJ |
| description | Abstract Background Schizophrenia is associated with multiple neurotransmitter disorders, including serotonin (5-hydroxytryptamine, 5-HT). The neuromodulatory action of serotonin on brain function largely depends on the action of specific subtypes of serotonin receptors. The serotonin receptor 1B (HTR1B) gene has been proposed to play putative roles in the development of multiple emotional and psychiatric disorders. Methods To study the relationship of HTR1B polymorphisms and schizophrenia, gene information was drawn from a cohort of 310 schizophrenic patients (152 men and 158 women) and 313 healthy controls (153 men and 160 women) of northern Han Chinese descent. The χ2 test was used to compare allele and genotype distributions between case and control groups. The haplotype and linkage equilibrium were also assessed in two group comparisons. Results We detected 14 SNPs. Male patients were observed to have higher frequencies of the A-allele and AA+AG genotype at rs1778258 than female patients (p = 0.012 and p = 0.015, respectively). Both the A-allele and AA+AG genotype were associated with schizophrenia risk (OR = 1.986 and OR = 2.061, respectively), although the statistical significance of the genotype was lost after Bonferroni correction. Linkage analysis showed that rs17273700, rs11568817, rs9361234 and rs58138557 polymorphisms exhibit strong linkage disequilibrium (LD). In addition, schizophrenic patients show stronger linkage between 11,568,817 and rs130058 than healthy controls. Conclusions HTR1B polymorphisms are associated with schizophrenia in the northern Han Chinese population, which provides an etiological reference for schizophrenia. |
| first_indexed | 2024-12-22T04:35:35Z |
| format | Article |
| id | doaj.art-2fb50f372f8e40f49a87285222439da3 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-22T04:35:35Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-2fb50f372f8e40f49a87285222439da32022-12-21T18:38:53ZengBMCBMC Psychiatry1471-244X2018-09-0118111110.1186/s12888-018-1849-xPolymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control studyXi Xia0Mei Ding1Jin-feng Xuan2Jia-xin Xing3Hao Pang4Bao-jie Wang5Jun Yao6School of Forensic Medicine, China Medical UniversitySchool of Forensic Medicine, China Medical UniversitySchool of Forensic Medicine, China Medical UniversitySchool of Forensic Medicine, China Medical UniversitySchool of Forensic Medicine, China Medical UniversitySchool of Forensic Medicine, China Medical UniversitySchool of Forensic Medicine, China Medical UniversityAbstract Background Schizophrenia is associated with multiple neurotransmitter disorders, including serotonin (5-hydroxytryptamine, 5-HT). The neuromodulatory action of serotonin on brain function largely depends on the action of specific subtypes of serotonin receptors. The serotonin receptor 1B (HTR1B) gene has been proposed to play putative roles in the development of multiple emotional and psychiatric disorders. Methods To study the relationship of HTR1B polymorphisms and schizophrenia, gene information was drawn from a cohort of 310 schizophrenic patients (152 men and 158 women) and 313 healthy controls (153 men and 160 women) of northern Han Chinese descent. The χ2 test was used to compare allele and genotype distributions between case and control groups. The haplotype and linkage equilibrium were also assessed in two group comparisons. Results We detected 14 SNPs. Male patients were observed to have higher frequencies of the A-allele and AA+AG genotype at rs1778258 than female patients (p = 0.012 and p = 0.015, respectively). Both the A-allele and AA+AG genotype were associated with schizophrenia risk (OR = 1.986 and OR = 2.061, respectively), although the statistical significance of the genotype was lost after Bonferroni correction. Linkage analysis showed that rs17273700, rs11568817, rs9361234 and rs58138557 polymorphisms exhibit strong linkage disequilibrium (LD). In addition, schizophrenic patients show stronger linkage between 11,568,817 and rs130058 than healthy controls. Conclusions HTR1B polymorphisms are associated with schizophrenia in the northern Han Chinese population, which provides an etiological reference for schizophrenia.http://link.springer.com/article/10.1186/s12888-018-1849-xSchizophreniaSingle-nucleotide polymorphisms (SNPs)Serotonin receptor 1B (HTR1B) |
| spellingShingle | Xi Xia Mei Ding Jin-feng Xuan Jia-xin Xing Hao Pang Bao-jie Wang Jun Yao Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study BMC Psychiatry Schizophrenia Single-nucleotide polymorphisms (SNPs) Serotonin receptor 1B (HTR1B) |
| title | Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study |
| title_full | Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study |
| title_fullStr | Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study |
| title_full_unstemmed | Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study |
| title_short | Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study |
| title_sort | polymorphisms in the human serotonin receptor 1b htr1b gene are associated with schizophrenia a case control study |
| topic | Schizophrenia Single-nucleotide polymorphisms (SNPs) Serotonin receptor 1B (HTR1B) |
| url | http://link.springer.com/article/10.1186/s12888-018-1849-x |
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