Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats
Background & Aim: Management/ treatment of illness and maintenance of well-being using herbal medicines is the oldest and most popular form of healthcare practice known to humankind that has been practiced by all cultures in all ages throughout the history of evolution. The ethanol extract of Ja...
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| Format: | Article |
| Language: | English |
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Islamic Azad University, Shahrekord Branch
2022-05-01
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| Series: | Journal of Herbal Drugs |
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| Online Access: | https://jhd.shahrekord.iau.ir/article_693310.html |
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| author | Chika Cecilia Unegbu Obinna Ajah Chinwendu Miriam Nnorom Josephat Chukwudi Onwusonye Chioma Adaeze Duru Obinna Mark Joel |
| author_facet | Chika Cecilia Unegbu Obinna Ajah Chinwendu Miriam Nnorom Josephat Chukwudi Onwusonye Chioma Adaeze Duru Obinna Mark Joel |
| author_sort | Chika Cecilia Unegbu |
| collection | DOAJ |
| description | Background & Aim: Management/ treatment of illness and maintenance of well-being using herbal medicines is the oldest and most popular form of healthcare practice known to humankind that has been practiced by all cultures in all ages throughout the history of evolution. The ethanol extract of Jatropha tanjorensis leave was evaluated for it pharmacological potency in alloxan-induced diabetes in albino rats.
Experimental: Twenty-four adult male albino rats weighing 120-180g were randomly divided into six groups of four rats per group. Group I (Normal control) were given 0.2 mL of water. Group II (Negative control): were untreated diabetic rats. Group III were Diabetic rats treated with reference drug (glibenclamide at 5 mg/kg b.wt) which served as positive control. Group IV – VI were Diabetic rats treated with Jatropha tanjorensis leaf extract at a dose of 200 mg/kg b.wt, 400 mg/kg b.wt, and 600 mg/kg b.wt, respectively. Administrations were done orally for 14 days. Blood was collected from the tail of the rats to determine the blood glucose level on the 4th, 9th and 14th day of the study.
Results: The extract significantly reduced the blood glucose level. The Jatropha tanjorensis leaf extract showed dose dependent significant (P<0.05) decrease in the triacylglycerol (TAG), low density lipoprotein (LDL), Cholesterol, total white blood cell (TWBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, urea, creatinine level as well as significant (P<0.05) increase in hemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC) and albumin level when compared with diabetic untreated group (negative control). Diabetic-related alteration in rat serum biochemical indices were significantly improved by the extract.
Recommended applications/industries: The outcome of the research gave credence to the folk use Jatropha tanjorensis leaf in the treatment of diabetes and its health related dysfunctions. |
| first_indexed | 2024-03-09T08:03:19Z |
| format | Article |
| id | doaj.art-2fb541a3adb44c0d9d627cf43fc2186c |
| institution | Directory Open Access Journal |
| issn | 2008-8884 2476-5392 |
| language | English |
| last_indexed | 2024-03-09T08:03:19Z |
| publishDate | 2022-05-01 |
| publisher | Islamic Azad University, Shahrekord Branch |
| record_format | Article |
| series | Journal of Herbal Drugs |
| spelling | doaj.art-2fb541a3adb44c0d9d627cf43fc2186c2023-12-03T00:35:05ZengIslamic Azad University, Shahrekord BranchJournal of Herbal Drugs2008-88842476-53922022-05-01131576410.30495/MEDHERB.2022.693310Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in ratsChika Cecilia Unegbu0Obinna Ajah 1Chinwendu Miriam Nnorom2Josephat Chukwudi Onwusonye3Chioma Adaeze Duru4 Obinna Mark Joel 5Department of Chemistry/Biochemistry, School of Industrial and Applied Sciences, Federal Polytechnic Nekede, Owerri NigeriaDepartment of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture Umudike.Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikwe University, Akwa, NigeriaDepartment of Biochemistry/Microbiology, School of Industrial and Applied Sciences, Federal Polytechnic Nekede, Owerri NigeriaDepartment of Pharmaceutical Technology, School of Industrial and Applied Sciences, Federal Polytechnic Nekede, Owerri Nigeria.Department of Biochemistry/Microbiology, School of Industrial and Applied Sciences, Federal Polytechnic Nekede, Owerri Nigeria.Background & Aim: Management/ treatment of illness and maintenance of well-being using herbal medicines is the oldest and most popular form of healthcare practice known to humankind that has been practiced by all cultures in all ages throughout the history of evolution. The ethanol extract of Jatropha tanjorensis leave was evaluated for it pharmacological potency in alloxan-induced diabetes in albino rats. Experimental: Twenty-four adult male albino rats weighing 120-180g were randomly divided into six groups of four rats per group. Group I (Normal control) were given 0.2 mL of water. Group II (Negative control): were untreated diabetic rats. Group III were Diabetic rats treated with reference drug (glibenclamide at 5 mg/kg b.wt) which served as positive control. Group IV – VI were Diabetic rats treated with Jatropha tanjorensis leaf extract at a dose of 200 mg/kg b.wt, 400 mg/kg b.wt, and 600 mg/kg b.wt, respectively. Administrations were done orally for 14 days. Blood was collected from the tail of the rats to determine the blood glucose level on the 4th, 9th and 14th day of the study. Results: The extract significantly reduced the blood glucose level. The Jatropha tanjorensis leaf extract showed dose dependent significant (P<0.05) decrease in the triacylglycerol (TAG), low density lipoprotein (LDL), Cholesterol, total white blood cell (TWBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, urea, creatinine level as well as significant (P<0.05) increase in hemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC) and albumin level when compared with diabetic untreated group (negative control). Diabetic-related alteration in rat serum biochemical indices were significantly improved by the extract. Recommended applications/industries: The outcome of the research gave credence to the folk use Jatropha tanjorensis leaf in the treatment of diabetes and its health related dysfunctions.https://jhd.shahrekord.iau.ir/article_693310.htmlantidiabeticantidyslipidemichepatoprotectivenephroprotective |
| spellingShingle | Chika Cecilia Unegbu Obinna Ajah Chinwendu Miriam Nnorom Josephat Chukwudi Onwusonye Chioma Adaeze Duru Obinna Mark Joel Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats Journal of Herbal Drugs antidiabetic antidyslipidemic hepatoprotective nephroprotective |
| title | Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats |
| title_full | Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats |
| title_fullStr | Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats |
| title_full_unstemmed | Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats |
| title_short | Antidiabetes, antidyslipidemia, hemoprotective, nehproprotective and hepatoprotective effect of ethanol extract of Jatropha tanjorensis leaf against alloxan induced diabetes in rats |
| title_sort | antidiabetes antidyslipidemia hemoprotective nehproprotective and hepatoprotective effect of ethanol extract of jatropha tanjorensis leaf against alloxan induced diabetes in rats |
| topic | antidiabetic antidyslipidemic hepatoprotective nephroprotective |
| url | https://jhd.shahrekord.iau.ir/article_693310.html |
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