Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Abstract Histone lysine methylation is thought to play a role in the pathogenesis of rheumatoid arthritis (RA). We previously reported aberrant expression of the gene encoding mixed-lineage leukemia 1 (MLL1), which catalyzes methylation of histone H3 lysine 4 (H3K4), in RA synovial fibroblasts (SFs)...

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Bibliographic Details
Main Authors: Keita Okamoto, Yasuto Araki, Yoshimi Aizaki, Shinya Tanaka, Yuho Kadono, Toshihide Mimura
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Rheumatoid arthritis
Synovial fibroblast
Histone lysine methylation
Cytokine
Chemokine
Online Access:https://doi.org/10.1038/s41598-024-60860-7

Internet

https://doi.org/10.1038/s41598-024-60860-7

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