Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications
So far, poly(L-lactic acid), PLLA nanosheets proved to be promising for wound healing. Such biodegradable materials are easy to prepare, bio-friendly, cost-effective, simple to apply and were shown to protect burn wounds and facilitate their healing. At the same time, certain metal ions are known to...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/15/22/8101 |
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| author | M. Q. Hafzan Ishak Prabakaran Shankar Marat E. Turabayev Takahiro Kondo Mitsuhiro Honda Stanislav O. Gurbatov Yosuke Okamura Satoru Iwamori Sergei A. Kulinich |
| author_facet | M. Q. Hafzan Ishak Prabakaran Shankar Marat E. Turabayev Takahiro Kondo Mitsuhiro Honda Stanislav O. Gurbatov Yosuke Okamura Satoru Iwamori Sergei A. Kulinich |
| author_sort | M. Q. Hafzan Ishak |
| collection | DOAJ |
| description | So far, poly(L-lactic acid), PLLA nanosheets proved to be promising for wound healing. Such biodegradable materials are easy to prepare, bio-friendly, cost-effective, simple to apply and were shown to protect burn wounds and facilitate their healing. At the same time, certain metal ions are known to be essential for wound healing, which is why this study was motivated by the idea of incorporating PLLA nanosheets with Zn<sup>2+</sup> ion containing nanoparticles. Upon being applied on wound, such polymer nanosheets should release Zn<sup>2+</sup> ions, which is expected to improve wound healing. The work thus focused on preparing PLLA nanosheets embedded with several kinds of Zn-containing nanoparticles, their characterization and ion-release behavior. ZnCl<sub>2</sub> and ZnO nanoparticles were chosen because of their different solubility in water, with the intention to see the dynamics of their Zn<sup>2+</sup> ion release in liquid medium with pH around 7.4. Interestingly, the prepared PLLA nanosheets demonstrated quit similar ion release rates, reaching the maximum concentration after about 10 h. This finding implies that such polymer materials can be promising as they are expected to release ions within several hours after their application on skin. |
| first_indexed | 2024-03-09T18:11:34Z |
| format | Article |
| id | doaj.art-2fb5d9db0810489290a7bb7b9bc1e362 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T18:11:34Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-2fb5d9db0810489290a7bb7b9bc1e3622023-11-24T09:04:11ZengMDPI AGMaterials1996-19442022-11-011522810110.3390/ma15228101Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical ApplicationsM. Q. Hafzan Ishak0Prabakaran Shankar1Marat E. Turabayev2Takahiro Kondo3Mitsuhiro Honda4Stanislav O. Gurbatov5Yosuke Okamura6Satoru Iwamori7Sergei A. Kulinich8Department of Mechanical Engineering, Tokai University, Hiratsuka 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka 259-1292, JapanInstitute of Automation and Control Processes, Far Eastern Branch, Russian Academy of Science, Vladivostok 690041, RussiaDepartment of Applied Chemistry, Tokai University, Hiratsuka 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka 259-1292, JapanDepartment of Mechanical Engineering, Tokai University, Hiratsuka 259-1292, JapanSo far, poly(L-lactic acid), PLLA nanosheets proved to be promising for wound healing. Such biodegradable materials are easy to prepare, bio-friendly, cost-effective, simple to apply and were shown to protect burn wounds and facilitate their healing. At the same time, certain metal ions are known to be essential for wound healing, which is why this study was motivated by the idea of incorporating PLLA nanosheets with Zn<sup>2+</sup> ion containing nanoparticles. Upon being applied on wound, such polymer nanosheets should release Zn<sup>2+</sup> ions, which is expected to improve wound healing. The work thus focused on preparing PLLA nanosheets embedded with several kinds of Zn-containing nanoparticles, their characterization and ion-release behavior. ZnCl<sub>2</sub> and ZnO nanoparticles were chosen because of their different solubility in water, with the intention to see the dynamics of their Zn<sup>2+</sup> ion release in liquid medium with pH around 7.4. Interestingly, the prepared PLLA nanosheets demonstrated quit similar ion release rates, reaching the maximum concentration after about 10 h. This finding implies that such polymer materials can be promising as they are expected to release ions within several hours after their application on skin.https://www.mdpi.com/1996-1944/15/22/8101biodegradable polymer nanosheetswound healinglaser ablation in liquidnanoparticlesZnOZnCl<sub>2</sub> |
| spellingShingle | M. Q. Hafzan Ishak Prabakaran Shankar Marat E. Turabayev Takahiro Kondo Mitsuhiro Honda Stanislav O. Gurbatov Yosuke Okamura Satoru Iwamori Sergei A. Kulinich Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications Materials biodegradable polymer nanosheets wound healing laser ablation in liquid nanoparticles ZnO ZnCl<sub>2</sub> |
| title | Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications |
| title_full | Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications |
| title_fullStr | Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications |
| title_full_unstemmed | Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications |
| title_short | Biodegradable Polymer Nanosheets Incorporated with Zn-Containing Nanoparticles for Biomedical Applications |
| title_sort | biodegradable polymer nanosheets incorporated with zn containing nanoparticles for biomedical applications |
| topic | biodegradable polymer nanosheets wound healing laser ablation in liquid nanoparticles ZnO ZnCl<sub>2</sub> |
| url | https://www.mdpi.com/1996-1944/15/22/8101 |
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