Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice

Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice

Objective: Osteoarthritis (OA), widely seen in the elderly, is featured by cartilage degradation, subchondral bone remolding, and synovium inflammation. Currently, there is no cure for OA development. Phillygenin (PHI), an active ingredient from the Forsythiae Fructus, possesses many biological prop...

Full description

Bibliographic Details
Main Authors:	Peng Zhang, Yesheng Jin, Wei Xia, Xiaotong Wang, Zhiqiang Zhou
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Series:	Journal of Orthopaedic Translation
Subjects:	Osteoarthritis Inflammation Oxidative stress Phillygenin Nrf2/NF-κB
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214031X23000177

Similar Items

Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways
by: Huan-Huan Xue, et al.
Published: (2023-01-01)

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo
by: Zengxin Jiang, et al.
Published: (2022-09-01)

Scutellarin ameliorates osteoarthritis by protecting chondrocytes and subchondral bone microstructure by inactivating NF-κB/MAPK signal transduction
by: Huan Yang, et al.
Published: (2022-11-01)

Stevioside attenuates osteoarthritis via regulating Nrf2/HO-1/NF-κB pathway
by: Jia Wu, et al.
Published: (2023-01-01)

Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway
by: Tianwen Ma, et al.
Published: (2022-10-01)

Therapeutic effect of demethylated hydroxylated phillygenin derivative on Helicobacter pylori infection
by: Ru-Jia Li, et al.
Published: (2023-05-01)

A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives
by: Cheng Wang, et al.
Published: (2023-10-01)

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy
by: Veera Ganesh Yerra, et al.
Published: (2013-01-01)

The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis
by: Li Wenzhao, et al.
Published: (2023-05-01)

Syringic acid (SA) inhibits the IL-1β-induced inflammation in mice chondrocytes and ameliorates the progression of osteoarthritis via the PTEN/AKT/NF-κB pathway
by: Yao Li, et al.
Published: (2023-08-01)

Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway
by: Guangxia Yang, et al.
Published: (2022-08-01)

Synergistic anti-infectious bronchitis virus activity of Phillygenin combined Baicalin by modulating respiratory microbiota and improving metabolic disorders
by: Haipeng Feng, et al.
Published: (2024-02-01)

Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
by: Haitao Chen, et al.
Published: (2023-01-01)

Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals
by: Francesca Gado, et al.
Published: (2023-01-01)

Nrf2 and NF-κB Signaling Pathways Contribute to Porphyra-334-Mediated Inhibition of UVA-Induced Inflammation in Skin Fibroblasts
by: Jina Ryu, et al.
Published: (2015-07-01)

Eupatilin Suppresses OVA-Induced Asthma by Inhibiting NF-κB and MAPK and Activating Nrf2 Signaling Pathways in Mice
by: Donghui Bai, et al.
Published: (2022-01-01)

Phloretamide Prevent Hepatic and Pancreatic Damage in Diabetic Male Rats by Modulating Nrf2 and NF-κB
by: Rasha Al-Hussan, et al.
Published: (2023-03-01)

Astaxanthin as a Modulator of Nrf2, NF-κB, and Their Crosstalk: Molecular Mechanisms and Possible Clinical Applications
by: Sergio Davinelli, et al.
Published: (2022-01-01)

κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway
by: Shi Yi, et al.
Published: (2023-11-01)

Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation
by: Ruijia Yang, et al.
Published: (2023-02-01)

Naringenin ameliorates myocardial injury in STZ-induced diabetic mice by reducing oxidative stress, inflammation and apoptosis via regulating the Nrf2 and NF-κB signaling pathways
by: Yongpeng He, et al.
Published: (2022-08-01)

Geniposide suppressed OX-LDL-induced osteoblast apoptosis by regulating the NRF2/NF-κB signaling pathway
by: Yaosheng Xiao, et al.
Published: (2023-08-01)

Schisandrol A Suppresses Catabolic Factor Expression by Blocking NF-κB Signaling in Osteoarthritis
by: Seong Jae Han, et al.
Published: (2021-03-01)

Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway
by: Lin Zhao, et al.
Published: (2024-01-01)

5-ALA/SFC Ameliorates Endotoxin-Induced Ocular Inflammation in Rats by Inhibiting the NF-κB Signaling Pathway and Activating the HO-1/Nrf2 Signaling Pathway
by: Yuya Otaka, et al.
Published: (2023-05-01)

Nrf2-Activating Bioactive Peptides Exert Anti-Inflammatory Activity through Inhibition of the NF-κB Pathway
by: Federica Tonolo, et al.
Published: (2022-04-01)

Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-α, NF-κB, and Bax
by: Ahmed M. Abd-Eldayem, et al.
Published: (2024-03-01)

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
by: Wen Gao, et al.
Published: (2022-02-01)

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway
by: Yongjun Ye, et al.
Published: (2023-03-01)

Preparation of Phillygenin-Hyaluronic acid composite milk-derived exosomes and its anti-hepatic fibrosis effect
by: Lihong Gong, et al.
Published: (2023-12-01)

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells
by: Da-Young Lee, et al.
Published: (2020-03-01)

Forsythia suspensa (Thunb.) Vahl extract ameliorates ulcerative colitis via inhibiting NLRP3 inflammasome activation through the TLR4/MyD88/NF‐κB pathway
by: Xiao Tong, et al.
Published: (2023-11-01)

Molecular Mechanisms Underlying the Anti-Inflammatory Properties of (R)-(-)-Carvone: Potential Roles of JNK1, Nrf2 and NF-κB
by: Cátia Sousa, et al.
Published: (2023-01-01)

Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
by: Katarzyna Papierska, et al.
Published: (2021-08-01)

α-Chaconine Facilitates Chondrocyte Pyroptosis and Nerve Ingrowth to Aggravate Osteoarthritis Progression by Activating NF-κB Signaling
by: Zhang Z, et al.
Published: (2022-10-01)

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway
by: Zhou Guo, et al.
Published: (2022-03-01)

The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress
by: Sinemyiz Atalay Ekiner, et al.
Published: (2022-11-01)

Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity
by: Asmaa I. Matouk, et al.
Published: (2023-03-01)

Unlocking the Potential: Novel NSAIDs Hybrids Unleash Chemopreventive Power toward Liver Cancer Cells through Nrf2, NF-κB, and MAPK Signaling Pathways
by: Maria Narożna, et al.
Published: (2023-07-01)

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation
by: María Luisa Castejón, et al.
Published: (2021-01-01)