Rational Truncation of Aptamer for Ultrasensitive Aptasensing of Chloramphenicol: Studies Using Bio-Layer Interferometry

Rational Truncation of Aptamer for Ultrasensitive Aptasensing of Chloramphenicol: Studies Using Bio-Layer Interferometry

Aptamers are an excellent choice for the selective detection of small molecules. However, the previously reported aptamer for chloramphenicol suffers from low affinity, probably as a result of steric hindrance due to its bulky nature (80 nucleotides) leading to lower sensitivity in analytical assays...

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Bibliographic Details
Main Authors: Richa Sharma, Monali Mukherjee, Praveena Bhatt, K. S. M. S. Raghavarao
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biosensors
Subjects:
antibiotics
affinity
biosensing
interferometry
nanoparticles
Online Access:https://www.mdpi.com/2079-6374/13/6/660

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