Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential
Neuroblastoma, a biologically heterogeneous tumor derived from neural crest cells, accounts for approximately 15% of childhood deaths from cancer. Recently, scientific literature has explored the role of cell adhesion molecules (CAMs) in cancer metastasis through cell detachment, migration, and inva...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.782186/full |
| _version_ | 1818141320442544128 |
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| author | Briana E. Heinly Christa N. Grant Christa N. Grant |
| author_facet | Briana E. Heinly Christa N. Grant Christa N. Grant |
| author_sort | Briana E. Heinly |
| collection | DOAJ |
| description | Neuroblastoma, a biologically heterogeneous tumor derived from neural crest cells, accounts for approximately 15% of childhood deaths from cancer. Recently, scientific literature has explored the role of cell adhesion molecules (CAMs) in cancer metastasis through cell detachment, migration, and invasion. Through a review of the current literature, it is evident that expression of different CAMs on neuroblastoma tumors is associated with favorable or unfavorable clinical prognosis. In patients diagnosed with neuroblastoma, treatment strategies include chemotherapy, surgery, radiotherapy, stem cell transplant, and more recently, immunotherapy and other targeted therapies. Long term survival remains poor despite multimodality treatment, especially for children with high-risk neuroblastoma, making it more necessary to explore innovative targeted therapies. CAMs have immense potential as therapeutic targets, but there is a need for growth and scientific exploration before CAM therapies become clinically useful. |
| first_indexed | 2024-12-11T10:58:00Z |
| format | Article |
| id | doaj.art-2fb7eee1a8744cd0ba2a78a76833198e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T10:58:00Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2fb7eee1a8744cd0ba2a78a76833198e2022-12-22T01:09:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.782186782186Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic PotentialBriana E. Heinly0Christa N. Grant1Christa N. Grant2Penn State College of Medicine, Hershey, PA, United StatesPenn State College of Medicine, Hershey, PA, United StatesDivision of Pediatric Surgery, Milton S. Hershey Medical Center, Hershey, PA, United StatesNeuroblastoma, a biologically heterogeneous tumor derived from neural crest cells, accounts for approximately 15% of childhood deaths from cancer. Recently, scientific literature has explored the role of cell adhesion molecules (CAMs) in cancer metastasis through cell detachment, migration, and invasion. Through a review of the current literature, it is evident that expression of different CAMs on neuroblastoma tumors is associated with favorable or unfavorable clinical prognosis. In patients diagnosed with neuroblastoma, treatment strategies include chemotherapy, surgery, radiotherapy, stem cell transplant, and more recently, immunotherapy and other targeted therapies. Long term survival remains poor despite multimodality treatment, especially for children with high-risk neuroblastoma, making it more necessary to explore innovative targeted therapies. CAMs have immense potential as therapeutic targets, but there is a need for growth and scientific exploration before CAM therapies become clinically useful.https://www.frontiersin.org/articles/10.3389/fonc.2022.782186/fullneuroblastomacell adhesion moleculestumorigenesismetastasisintegrincadherin |
| spellingShingle | Briana E. Heinly Christa N. Grant Christa N. Grant Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential Frontiers in Oncology neuroblastoma cell adhesion molecules tumorigenesis metastasis integrin cadherin |
| title | Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential |
| title_full | Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential |
| title_fullStr | Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential |
| title_full_unstemmed | Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential |
| title_short | Cell Adhesion Molecules in Neuroblastoma: Complex Roles, Therapeutic Potential |
| title_sort | cell adhesion molecules in neuroblastoma complex roles therapeutic potential |
| topic | neuroblastoma cell adhesion molecules tumorigenesis metastasis integrin cadherin |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.782186/full |
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