RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.
Bibliographic Details
| Main Authors: |
Xia Wang,
Jin Wang,
Yu-Man Tsui,
Chaoran Shi,
Ying Wang,
Xin Zhang,
Qian Yan,
Miao Chen,
Chen Jiang,
Yun-Fei Yuan,
Chun-Ming Wong,
Ming Liu,
Zeng-yu Feng,
Honglin Chen,
Irene Oi Lin Ng,
Lingxi Jiang,
Xin-Yuan Guan |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21828-7
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