RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21828-7 |
| _version_ | 1818752616813821952 |
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| author | Xia Wang Jin Wang Yu-Man Tsui Chaoran Shi Ying Wang Xin Zhang Qian Yan Miao Chen Chen Jiang Yun-Fei Yuan Chun-Ming Wong Ming Liu Zeng-yu Feng Honglin Chen Irene Oi Lin Ng Lingxi Jiang Xin-Yuan Guan |
| author_facet | Xia Wang Jin Wang Yu-Man Tsui Chaoran Shi Ying Wang Xin Zhang Qian Yan Miao Chen Chen Jiang Yun-Fei Yuan Chun-Ming Wong Ming Liu Zeng-yu Feng Honglin Chen Irene Oi Lin Ng Lingxi Jiang Xin-Yuan Guan |
| author_sort | Xia Wang |
| collection | DOAJ |
| description | RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification. |
| first_indexed | 2024-12-18T04:54:18Z |
| format | Article |
| id | doaj.art-2fb80e31fc6b42d4945a5ded63e83e44 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:54:18Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2fb80e31fc6b42d4945a5ded63e83e442022-12-21T21:20:19ZengNature PortfolioNature Communications2041-17232021-03-0112111410.1038/s41467-021-21828-7RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2Xia Wang0Jin Wang1Yu-Man Tsui2Chaoran Shi3Ying Wang4Xin Zhang5Qian Yan6Miao Chen7Chen Jiang8Yun-Fei Yuan9Chun-Ming Wong10Ming Liu11Zeng-yu Feng12Honglin Chen13Irene Oi Lin Ng14Lingxi Jiang15Xin-Yuan Guan16Department of Clinical Oncology, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongState key Laboratory of Liver Research, The University of Hong KongDepartment of Clinical Oncology, The University of Hong KongDepartment of Clinical Oncology, The University of Hong KongState key Laboratory of Liver Research, The University of Hong KongDepartment of Clinical Oncology, The University of Hong KongDepartment of Clinical Oncology, The University of Hong KongDepartment of Clinical Oncology, The University of Hong KongState Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer CenterState key Laboratory of Liver Research, The University of Hong KongDepartment of Clinical Oncology, The University of Hong KongDepartment of General Surgery, Ruijin Hospital, Shanghai JiaoTong University School of MedicineDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongState key Laboratory of Liver Research, The University of Hong KongState key Laboratory of Liver Research, The University of Hong KongDepartment of Clinical Oncology, The University of Hong KongRALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.https://doi.org/10.1038/s41467-021-21828-7 |
| spellingShingle | Xia Wang Jin Wang Yu-Man Tsui Chaoran Shi Ying Wang Xin Zhang Qian Yan Miao Chen Chen Jiang Yun-Fei Yuan Chun-Ming Wong Ming Liu Zeng-yu Feng Honglin Chen Irene Oi Lin Ng Lingxi Jiang Xin-Yuan Guan RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 Nature Communications |
| title | RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 |
| title_full | RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 |
| title_fullStr | RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 |
| title_full_unstemmed | RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 |
| title_short | RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2 |
| title_sort | ralyl increases hepatocellular carcinoma stemness by sustaining the mrna stability of tgf β2 |
| url | https://doi.org/10.1038/s41467-021-21828-7 |
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