Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies
Drug resistance is the main obstacle to achieving a cure in many cancer patients. Reactive oxygen species (ROS) are master regulators of cancer development that act through complex mechanisms. Remarkably, ROS levels and antioxidant content are typically higher in drug-resistant cancer cells than in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223008260 |
| _version_ | 1797744116861239296 |
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| author | Xiaoting Zhou Biao An Yi Lin Yanghong Ni Xia Zhao Xiao Liang |
| author_facet | Xiaoting Zhou Biao An Yi Lin Yanghong Ni Xia Zhao Xiao Liang |
| author_sort | Xiaoting Zhou |
| collection | DOAJ |
| description | Drug resistance is the main obstacle to achieving a cure in many cancer patients. Reactive oxygen species (ROS) are master regulators of cancer development that act through complex mechanisms. Remarkably, ROS levels and antioxidant content are typically higher in drug-resistant cancer cells than in non-resistant and normal cells, and have been shown to play a central role in modulating drug resistance. Therefore, determining the underlying functions of ROS in the modulation of drug resistance will contribute to develop therapies that sensitize cancer resistant cells by leveraging ROS modulation. In this review, we summarize the notable literature on the sources and regulation of ROS production and highlight the complex roles of ROS in cancer chemoresistance, encompassing transcription factor–mediated chemoresistance, maintenance of cancer stem cells, and their impact on the tumor microenvironment. We also discuss the potential of ROS-targeted therapies in overcoming tumor therapeutic resistance. |
| first_indexed | 2024-03-12T15:05:07Z |
| format | Article |
| id | doaj.art-2fb92838bb414d12bc491cb99a967f1c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:05:07Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-2fb92838bb414d12bc491cb99a967f1c2023-08-13T04:52:22ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115036Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategiesXiaoting Zhou0Biao An1Yi Lin2Yanghong Ni3Xia Zhao4Xiao Liang5Department of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, PR ChinaDepartment of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, PR ChinaDepartment of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, PR ChinaDepartment of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, PR ChinaDepartment of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, PR ChinaCorresponding author.; Department of Gynecology and Obstetrics, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, PR ChinaDrug resistance is the main obstacle to achieving a cure in many cancer patients. Reactive oxygen species (ROS) are master regulators of cancer development that act through complex mechanisms. Remarkably, ROS levels and antioxidant content are typically higher in drug-resistant cancer cells than in non-resistant and normal cells, and have been shown to play a central role in modulating drug resistance. Therefore, determining the underlying functions of ROS in the modulation of drug resistance will contribute to develop therapies that sensitize cancer resistant cells by leveraging ROS modulation. In this review, we summarize the notable literature on the sources and regulation of ROS production and highlight the complex roles of ROS in cancer chemoresistance, encompassing transcription factor–mediated chemoresistance, maintenance of cancer stem cells, and their impact on the tumor microenvironment. We also discuss the potential of ROS-targeted therapies in overcoming tumor therapeutic resistance.http://www.sciencedirect.com/science/article/pii/S0753332223008260ROSCellular redox balanceChemoresistanceTarget therapy |
| spellingShingle | Xiaoting Zhou Biao An Yi Lin Yanghong Ni Xia Zhao Xiao Liang Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies Biomedicine & Pharmacotherapy ROS Cellular redox balance Chemoresistance Target therapy |
| title | Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies |
| title_full | Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies |
| title_fullStr | Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies |
| title_full_unstemmed | Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies |
| title_short | Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies |
| title_sort | molecular mechanisms of ros modulated cancer chemoresistance and therapeutic strategies |
| topic | ROS Cellular redox balance Chemoresistance Target therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223008260 |
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