Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9’s Antiviral Effect via Nsp11 Endoribonuclease Activity

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9’s Antiviral Effect via Nsp11 Endoribonuclease Activity

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry worldwide. Our previous study had indicated that proprotein convertase subtilisin/kexin type 9 (PCSK9) was a responsive gene in porcine alveolar macrophages (PAMs) upon PRRSV infe...

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Bibliographic Details
Main Authors: Yujiao Zhang, Fei Gao, Liwei Li, Kuan Zhao, Shan Jiang, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Changlong Liu, Guangzhi Tong
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
porcine reproductive and respiratory syndrome virus
PCSK9
CD163
nsp11
lysosome
endoribonuclease activity
Online Access:https://www.mdpi.com/1999-4915/12/6/655

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