Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers
The advent of vaccines against SARS-CoV-2 has drastically reduced the level of hospitalization with severe COVID-19 disease in infected individuals. However, the diffusion of variants of concern still challenge the protection conferred by vaccines raised against the wild-type form of the virus. Here...
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MDPI AG
2022-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/12/2605 |
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| author | Maximiliano Mollura Riccardo Sarti Riccardo Levi Chiara Pozzi Elena Azzolini Letterio S. Politi Alberto Mantovani Riccardo Barbieri Maria Rescigno |
| author_facet | Maximiliano Mollura Riccardo Sarti Riccardo Levi Chiara Pozzi Elena Azzolini Letterio S. Politi Alberto Mantovani Riccardo Barbieri Maria Rescigno |
| author_sort | Maximiliano Mollura |
| collection | DOAJ |
| description | The advent of vaccines against SARS-CoV-2 has drastically reduced the level of hospitalization with severe COVID-19 disease in infected individuals. However, the diffusion of variants of concern still challenge the protection conferred by vaccines raised against the wild-type form of the virus. Here, we have characterized the antibody response to the BNT162b2 (Comirnaty) mRNA vaccine in patients infected with the Omicron variant. We analyzed a population of 4354 vaccinated healthcare workers (HCW) from 7 different hospitals in Italy and monitored infection with SARS-CoV-2 Omicron. We correlated infection with the antibody response after vaccination. We found that a lower level of IgG, younger age, and the presence of allergies correlate with increased infection during the Omicron wave, and that infections correlate with wild-type spike protein antibody titers below 350 BAU/mL. These results support the necessity of a fourth booster dose, particularly for individuals with lower levels of antibodies. |
| first_indexed | 2024-03-09T15:44:32Z |
| format | Article |
| id | doaj.art-2fba08eb6f304ab9a7be6a95182e30ac |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T15:44:32Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-2fba08eb6f304ab9a7be6a95182e30ac2023-11-24T18:36:24ZengMDPI AGViruses1999-49152022-11-011412260510.3390/v14122605Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare WorkersMaximiliano Mollura0Riccardo Sarti1Riccardo Levi2Chiara Pozzi3Elena Azzolini4Letterio S. Politi5Alberto Mantovani6Riccardo Barbieri7Maria Rescigno8Department of Electronic, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Emanuele, 20072 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Emanuele, 20072 Milan, ItalyIRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, ItalyIRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Emanuele, 20072 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Emanuele, 20072 Milan, ItalyDepartment of Electronic, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Emanuele, 20072 Milan, ItalyThe advent of vaccines against SARS-CoV-2 has drastically reduced the level of hospitalization with severe COVID-19 disease in infected individuals. However, the diffusion of variants of concern still challenge the protection conferred by vaccines raised against the wild-type form of the virus. Here, we have characterized the antibody response to the BNT162b2 (Comirnaty) mRNA vaccine in patients infected with the Omicron variant. We analyzed a population of 4354 vaccinated healthcare workers (HCW) from 7 different hospitals in Italy and monitored infection with SARS-CoV-2 Omicron. We correlated infection with the antibody response after vaccination. We found that a lower level of IgG, younger age, and the presence of allergies correlate with increased infection during the Omicron wave, and that infections correlate with wild-type spike protein antibody titers below 350 BAU/mL. These results support the necessity of a fourth booster dose, particularly for individuals with lower levels of antibodies.https://www.mdpi.com/1999-4915/14/12/2605COVID-19SARS-CoV-2 Omicron variantvaccineIgG |
| spellingShingle | Maximiliano Mollura Riccardo Sarti Riccardo Levi Chiara Pozzi Elena Azzolini Letterio S. Politi Alberto Mantovani Riccardo Barbieri Maria Rescigno Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers Viruses COVID-19 SARS-CoV-2 Omicron variant vaccine IgG |
| title | Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers |
| title_full | Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers |
| title_fullStr | Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers |
| title_full_unstemmed | Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers |
| title_short | Antibody Titer Correlates with Omicron Infection in Vaccinated Healthcare Workers |
| title_sort | antibody titer correlates with omicron infection in vaccinated healthcare workers |
| topic | COVID-19 SARS-CoV-2 Omicron variant vaccine IgG |
| url | https://www.mdpi.com/1999-4915/14/12/2605 |
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