Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four fl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2007-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/12/9/2130/ |
| _version_ | 1819091961447972864 |
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| author | Moonso Park Mankil Jung |
| author_facet | Moonso Park Mankil Jung |
| author_sort | Moonso Park |
| collection | DOAJ |
| description | In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED). |
| first_indexed | 2024-12-21T22:48:02Z |
| format | Article |
| id | doaj.art-2fba33dc381c406793170e8ec191e116 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T22:48:02Z |
| publishDate | 2007-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2fba33dc381c406793170e8ec191e1162022-12-21T18:47:38ZengMDPI AGMolecules1420-30492007-09-011292130213910.3390/12092130Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosaMoonso ParkMankil JungIn a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).http://www.mdpi.com/1420-3049/12/9/2130/AcetylcholineesteraseAgrimonia pilosaquercetintiliroside3-methoxyquercetin |
| spellingShingle | Moonso Park Mankil Jung Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa Molecules Acetylcholineesterase Agrimonia pilosa quercetin tiliroside 3-methoxyquercetin |
| title | Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa |
| title_full | Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa |
| title_fullStr | Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa |
| title_full_unstemmed | Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa |
| title_short | Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa |
| title_sort | acetylcholinesterase inhibition by flavonoids from agrimonia pilosa |
| topic | Acetylcholineesterase Agrimonia pilosa quercetin tiliroside 3-methoxyquercetin |
| url | http://www.mdpi.com/1420-3049/12/9/2130/ |
| work_keys_str_mv | AT moonsopark acetylcholinesteraseinhibitionbyflavonoidsfromagrimoniapilosa AT mankiljung acetylcholinesteraseinhibitionbyflavonoidsfromagrimoniapilosa |