Preclinical Challenges in Proton Minibeam Radiotherapy: Physics and Biomedical Aspects

Preclinical Challenges in Proton Minibeam Radiotherapy: Physics and Biomedical Aspects

The concept of spatial fractionation in radiotherapy was developed for better sparing of normal tissue in the entrance channel of radiation. Spatial fractionation utilizing proton minibeam radiotherapy (pMBRT) promises to be advantageous compared to X-ray minibeams due to higher dose conformity at t...

Full description

Bibliographic Details
Main Authors:	Gerd Datzmann, Matthias Sammer, Stefanie Girst, Michael Mayerhofer, Günther Dollinger, Judith Reindl
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Physics
Subjects:	proton minibeam radio therapy spatial fractionation linear accelerator preclinic irradiation facility pencil beam scanning
Online Access:	https://www.frontiersin.org/articles/10.3389/fphy.2020.568206/full

Similar Items

Longitudinally Heterogeneous Tumor Dose Optimizes Proton Broadbeam, Interlaced Minibeam, and FLASH Therapy
by: Matthias Sammer, et al.
Published: (2022-10-01)

Biological and Mechanical Synergies to Deal With Proton Therapy Pitfalls: Minibeams, FLASH, Arcs, and Gantryless Rooms
by: Alejandro Mazal, et al.
Published: (2021-01-01)

Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance
by: Ramon Ortiz, et al.
Published: (2021-12-01)

First Evaluation of Temporal and Spatial Fractionation in Proton Minibeam Radiation Therapy of Glioma-Bearing Rats
by: Annaïg Bertho, et al.
Published: (2021-09-01)

Dose Profile Modulation of Proton Minibeam for Clinical Application
by: Myeongsoo Kim, et al.
Published: (2022-06-01)

Converging Proton Minibeams with Magnetic Fields for Optimized Radiation Therapy: A Proof of Concept
by: Marco Cavallone, et al.
Published: (2021-12-01)

Proton minibeam radiation therapy: a promising therapeutic approach for radioresistant tumors
by: Prezado, Yolanda
Published: (2021-12-01)

Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model
by: Harry Scherthan, et al.
Published: (2022-03-01)

Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams
by: Tim Schneider, et al.
Published: (2021-09-01)

Monte Carlo Comparison of Proton and Helium-ion Minibeam Generation Techniques
by: Tim Schneider, et al.
Published: (2021-03-01)

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors
by: Lennart Volz, et al.
Published: (2023-06-01)

Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
by: Michael Mayerhofer, et al.
Published: (2021-01-01)

Orthovoltage X-ray Minibeam Radiation Therapy for the Treatment of Ocular Tumours—An In Silico Evaluation
by: Tim Schneider, et al.
Published: (2023-01-01)

X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom
by: Marios Sotiropoulos, et al.
Published: (2021-03-01)

Dosimetric comparison of intensity-modulated proton radiotherapy versus intensity-modulated photon-based radiotherapy for breast cancer
by: Lin Ruihe, et al.
Published: (2021-01-01)

A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy
by: Yolanda Prezado, et al.
Published: (2021-03-01)

Combined proton radiography and irradiation for high-precision preclinical studies in small animals
by: Moritz Schneider, et al.
Published: (2022-08-01)

Dosimetric Comparison of Various Spot Placement Techniques in Proton Pencil Beam Scanning
by: Mahboob ur Rehman, PhD, et al.
Published: (2022-01-01)

FLASH Irradiation with Proton Beams: Beam Characteristics and Their Implications for Beam Diagnostics
by: Konrad P. Nesteruk, et al.
Published: (2021-03-01)

Proton Radiotherapy for Patients With Oligometastatic Breast Cancer Involving the Sternum
by: Andrew Johnson, BS, et al.
Published: (2021-11-01)

Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size.
by: Matthias Sammer, et al.
Published: (2019-01-01)

Clinical Characterization of a Table Mounted Range Shifter Board for Synchrotron-Based Intensity Modulated Proton Therapy for Pediatric Craniospinal Irradiation
by: William T. Hrinivich, et al.
Published: (2023-05-01)

Characterization and performance evaluation of the first-proton therapy facility in India
by: Dayananda Sharma Shamurailatpam, et al.
Published: (2020-01-01)

Applications of various range shifters for proton pencil beam scanning radiotherapy
by: Haibo Lin, et al.
Published: (2021-08-01)

A GPU-based Pencil Beam Algorithm for Dose Calculations in Proton Radiation Therapy
by: Georgios Kalantzis, et al.
Published: (2015-11-01)

Experimental assessment of proton dose calculation accuracy in small-field delivery using a mevion S250 proton therapy system
by: Kyle D DePew, et al.
Published: (2018-01-01)

In Vivo Radiobiological Investigations with the TOP-IMPLART Proton Beam on a Medulloblastoma Mouse Model
by: Daniela Giovannini, et al.
Published: (2023-05-01)

Successful Implementation of Image-Guided Pencil-Beam Scanning Proton Therapy in Medulloblastomas
by: Anindita Das, et al.
Published: (2023-11-01)

Oxygen Depletion in Proton Spot Scanning: A Tool for Exploring the Conditions Needed for FLASH
by: Bethany C. Rothwell, et al.
Published: (2021-11-01)

Small field proton irradiation for in vivo studies: Potential and limitations when adapting clinical infrastructure
by: Monika Clausen, et al.
Published: (2023-11-01)

Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model.
by: Matthias Sammer, et al.
Published: (2019-01-01)

Applications of Machine Learning to Improve the Clinical Viability of Compton Camera Based in vivo Range Verification in Proton Radiotherapy
by: Jerimy C. Polf, et al.
Published: (2022-04-01)

In Vitro Comparison of Passive and Active Clinical Proton Beams
by: Anna Michaelidesová, et al.
Published: (2020-08-01)

Preclinical Dosimetry for Small Animal Radiation Research in Proton Therapy: A Feasibility Study
by: Fatih Biltekin, Ph.D., et al.
Published: (2023-04-01)

Proton Bragg Peak FLASH Enables Organ Sparing and Ultra-High Dose-Rate Delivery: Proof of Principle in Recurrent Head and Neck Cancer
by: Michael Pennock, et al.
Published: (2023-07-01)

Survival of tumor cells after proton irradiation with ultra-high dose rates
by: Belka Claus, et al.
Published: (2011-10-01)

Proceedings of the Workshop on Applications of High Intensity Proton Accelerators : Fermilab, Chicago, 19-21 October 2009 /
by: Workshop on Applications of High Intensity Proton Accelerators (2009 : Fermi National Accelerator Laboratory), et al.
Published: (c201)

Dosimetric Deviations of Bragg-Peak Position Shifts in Uniform Magnetic Fields for Magnetic Resonance Imaging-Guiding Proton Radiotherapy: A Monte Carlo Study
by: Xiaowa Wang, et al.
Published: (2021-08-01)

Proton therapy with a fixed beamline for skull-base chordomas and chondrosarcomas: outcomes and toxicity
by: Konstantin Gordon, et al.
Published: (2021-12-01)

Proton Therapy in the Management of Pancreatic Cancer
by: Jana M. Kobeissi, et al.
Published: (2022-06-01)