The immune factors have complex causal regulation effects on inflammatory bowel disease
BackgroundAlthough a correlation between immune cell phenotypes and inflammatory bowel disease (IBD) has been established, a causal relationship remains unestablished.MethodsTo assess causal associations between immune cell phenotypes and IBD and its subtypes, we employed Mendelian randomization (MR...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1322673/full |
| _version_ | 1797348206774845440 |
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| author | Binxu Qiu Tao Zhang Xinxin Qin Shengjie Ma Quan Wang |
| author_facet | Binxu Qiu Tao Zhang Xinxin Qin Shengjie Ma Quan Wang |
| author_sort | Binxu Qiu |
| collection | DOAJ |
| description | BackgroundAlthough a correlation between immune cell phenotypes and inflammatory bowel disease (IBD) has been established, a causal relationship remains unestablished.MethodsTo assess causal associations between immune cell phenotypes and IBD and its subtypes, we employed Mendelian randomization (MR) methods and genome-wide association studies (GWAS) summary statistics. The primary outcomes were determined based on the inverse variance weighting (IVW) results, with the assessment of heterogeneity and pleiotropy conducted through Cochrane’s Q-test and MR-Egger. The stability of the MR results was then examined using leave-one-out analysis, and false discovery rate (FDR) correction was applied to evaluate the strength of the causal relationship between exposure and outcome. Furthermore, to identify immunophenotypes strongly associated with IBD, a meta-integration of the effect values of all positive results in both datasets was conducted.ResultsThe analysis of 731 immune cell phenotypes and IBD using MR techniques revealed potential causal associations between 26 phenotypes and IBD. Subsequent meta-integration of the two datasets provided evidence of solid causal associations between 18 immune phenotypes and IBD and its subtypes. Nominal causal associations were also identified in the remaining eight immune phenotypes and IBD and its subtypes.ConclusionOur study confirms causal solid associations between 18 immune phenotypes and IBD, thus guiding future clinical studies. |
| first_indexed | 2024-03-08T12:02:25Z |
| format | Article |
| id | doaj.art-2fbafaa9a1d340f5bec38e7fe9263be8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T12:02:25Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2fbafaa9a1d340f5bec38e7fe9263be82024-01-23T15:34:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.13226731322673The immune factors have complex causal regulation effects on inflammatory bowel diseaseBinxu QiuTao ZhangXinxin QinShengjie MaQuan WangBackgroundAlthough a correlation between immune cell phenotypes and inflammatory bowel disease (IBD) has been established, a causal relationship remains unestablished.MethodsTo assess causal associations between immune cell phenotypes and IBD and its subtypes, we employed Mendelian randomization (MR) methods and genome-wide association studies (GWAS) summary statistics. The primary outcomes were determined based on the inverse variance weighting (IVW) results, with the assessment of heterogeneity and pleiotropy conducted through Cochrane’s Q-test and MR-Egger. The stability of the MR results was then examined using leave-one-out analysis, and false discovery rate (FDR) correction was applied to evaluate the strength of the causal relationship between exposure and outcome. Furthermore, to identify immunophenotypes strongly associated with IBD, a meta-integration of the effect values of all positive results in both datasets was conducted.ResultsThe analysis of 731 immune cell phenotypes and IBD using MR techniques revealed potential causal associations between 26 phenotypes and IBD. Subsequent meta-integration of the two datasets provided evidence of solid causal associations between 18 immune phenotypes and IBD and its subtypes. Nominal causal associations were also identified in the remaining eight immune phenotypes and IBD and its subtypes.ConclusionOur study confirms causal solid associations between 18 immune phenotypes and IBD, thus guiding future clinical studies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1322673/fullinflammatory bowel diseasecausal relationshipMendelian randomizationCrohn’s diseaseulcerative colitis |
| spellingShingle | Binxu Qiu Tao Zhang Xinxin Qin Shengjie Ma Quan Wang The immune factors have complex causal regulation effects on inflammatory bowel disease Frontiers in Immunology inflammatory bowel disease causal relationship Mendelian randomization Crohn’s disease ulcerative colitis |
| title | The immune factors have complex causal regulation effects on inflammatory bowel disease |
| title_full | The immune factors have complex causal regulation effects on inflammatory bowel disease |
| title_fullStr | The immune factors have complex causal regulation effects on inflammatory bowel disease |
| title_full_unstemmed | The immune factors have complex causal regulation effects on inflammatory bowel disease |
| title_short | The immune factors have complex causal regulation effects on inflammatory bowel disease |
| title_sort | immune factors have complex causal regulation effects on inflammatory bowel disease |
| topic | inflammatory bowel disease causal relationship Mendelian randomization Crohn’s disease ulcerative colitis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1322673/full |
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