Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders
Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neuro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/3/1433 |
| _version_ | 1797417280948142080 |
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| author | Carl Randall Harrell Ana Volarevic Valentin Djonov Vladislav Volarevic |
| author_facet | Carl Randall Harrell Ana Volarevic Valentin Djonov Vladislav Volarevic |
| author_sort | Carl Randall Harrell |
| collection | DOAJ |
| description | Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders. |
| first_indexed | 2024-03-09T06:16:25Z |
| format | Article |
| id | doaj.art-2fbd88caace54c84aaf6403b0448f9cc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T06:16:25Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2fbd88caace54c84aaf6403b0448f9cc2023-12-03T11:52:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01223143310.3390/ijms22031433Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive DisordersCarl Randall Harrell0Ana Volarevic1Valentin Djonov2Vladislav Volarevic3Regenerative Processing Plant, LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684, USADepartment of Cognitive Psychology, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, SerbiaInstitute of Anatomy, University of Bern, Baltzerstrasse 2, 3012 Bern, SwitzerlandDepartment of Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, SerbiaMesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.https://www.mdpi.com/1422-0067/22/3/1433mesenchymal stem cellsexosomesneurocognitive disorders |
| spellingShingle | Carl Randall Harrell Ana Volarevic Valentin Djonov Vladislav Volarevic Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders International Journal of Molecular Sciences mesenchymal stem cells exosomes neurocognitive disorders |
| title | Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders |
| title_full | Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders |
| title_fullStr | Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders |
| title_short | Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders |
| title_sort | mesenchymal stem cell derived exosomes as new remedy for the treatment of neurocognitive disorders |
| topic | mesenchymal stem cells exosomes neurocognitive disorders |
| url | https://www.mdpi.com/1422-0067/22/3/1433 |
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