An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis
Abstract Purpose This study aimed to evaluate the efficacy and safety of montelukast (Mon) + fluticasone propionate (Flu) versus Flu in the treatment of cough variant asthma (CVA) in children. Methods Eligible documents were selected from various databases. Weighted mean difference (WMD) and 95% con...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-023-02721-z |
| _version_ | 1797398194866356224 |
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| author | Zhengbo Wei Sheng Li |
| author_facet | Zhengbo Wei Sheng Li |
| author_sort | Zhengbo Wei |
| collection | DOAJ |
| description | Abstract Purpose This study aimed to evaluate the efficacy and safety of montelukast (Mon) + fluticasone propionate (Flu) versus Flu in the treatment of cough variant asthma (CVA) in children. Methods Eligible documents were selected from various databases. Weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate continuous variables, and categorical variables were evaluated using risk ratio (RR) and 95% CI. Heterogeneity analysis was performed using Cochran’s Q test and I 2 statistics, followed by sensitivity analysis and publication bias evaluation. Results Nine studies were included, and Flu + Mon was found to significantly improve the total effective rate and reduce cough recurrence compared to Flu. The cough remission and disappearance times in the Mon + Flu group were significantly lower than those in the Flu group. FEV1% recovery in the Mon + Flu group was significantly better than that in the Flu group. Conclusion Mon + Flu is effective and safe for the treatment of CVA in children. |
| first_indexed | 2024-03-09T01:21:15Z |
| format | Article |
| id | doaj.art-2fbde043fcc6439bb840e8907624ed7f |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-09T01:21:15Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-2fbde043fcc6439bb840e8907624ed7f2023-12-10T12:05:55ZengBMCBMC Pulmonary Medicine1471-24662023-12-0123111010.1186/s12890-023-02721-zAn efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysisZhengbo Wei0Sheng Li1Department of Pediatrics, The Affiliated Yancheng Maternity&Child Health Hospital of Yangzhou University Medical SchoolDepartment of Pediatrics, The Affiliated Yancheng Maternity&Child Health Hospital of Yangzhou University Medical SchoolAbstract Purpose This study aimed to evaluate the efficacy and safety of montelukast (Mon) + fluticasone propionate (Flu) versus Flu in the treatment of cough variant asthma (CVA) in children. Methods Eligible documents were selected from various databases. Weighted mean difference (WMD) and 95% confidence interval (CI) were used to evaluate continuous variables, and categorical variables were evaluated using risk ratio (RR) and 95% CI. Heterogeneity analysis was performed using Cochran’s Q test and I 2 statistics, followed by sensitivity analysis and publication bias evaluation. Results Nine studies were included, and Flu + Mon was found to significantly improve the total effective rate and reduce cough recurrence compared to Flu. The cough remission and disappearance times in the Mon + Flu group were significantly lower than those in the Flu group. FEV1% recovery in the Mon + Flu group was significantly better than that in the Flu group. Conclusion Mon + Flu is effective and safe for the treatment of CVA in children.https://doi.org/10.1186/s12890-023-02721-zCough variant asthmaFluticasone propionateMeta-analysisMontelukast |
| spellingShingle | Zhengbo Wei Sheng Li An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis BMC Pulmonary Medicine Cough variant asthma Fluticasone propionate Meta-analysis Montelukast |
| title | An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis |
| title_full | An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis |
| title_fullStr | An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis |
| title_full_unstemmed | An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis |
| title_short | An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis |
| title_sort | efficacy and safety evaluation of montelukast fluticasone propionate vs fluticasone propionate in the treatment of cough variant asthma in children a meta analysis |
| topic | Cough variant asthma Fluticasone propionate Meta-analysis Montelukast |
| url | https://doi.org/10.1186/s12890-023-02721-z |
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