Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers
This study was designed to evaluate the effects of different doses of the fibrous roots of <i>Polygonatum cyrtonema</i> Hua on the growth performance, slaughter parameters, meat quality, immune function, cytokines, antioxidant capacity, and intestinal morphology of white-feathered broile...
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MDPI AG
2023-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/11/1627 |
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| author | Tianlu Zhang Dong Zhou Miaofen Chen Hui Zou Qi Tang Ying Lu Yajie Zheng |
| author_facet | Tianlu Zhang Dong Zhou Miaofen Chen Hui Zou Qi Tang Ying Lu Yajie Zheng |
| author_sort | Tianlu Zhang |
| collection | DOAJ |
| description | This study was designed to evaluate the effects of different doses of the fibrous roots of <i>Polygonatum cyrtonema</i> Hua on the growth performance, slaughter parameters, meat quality, immune function, cytokines, antioxidant capacity, and intestinal morphology of white-feathered broilers. Also, the mechanism to improve immune functions of broilers was explored through network pharmacology and molecular docking technology. A total of 360 AA-white-feathered broilers were randomly divided into six groups (not separated by sex), with six repetitions per group (<i>n</i> = 10). The groups were as follows: basal diet (CON group), basal diet supplemented with 300 mg/kg aureomycin (ANT group), basal diet supplemented with 2%, 3%, and 4% fibrous root raw powder (LD, MD, and HD group), or basal diet supplemented with 3% fibrous root processed powder (PR group), in a 42-day experiment. The dietary inclusion of <i>P. cyrtonema</i> fibrous roots increased slaughter performance (<i>p</i> < 0.05), reduced the fat rate (<i>p</i> < 0.05), improved intestinal morphology (<i>p</i> < 0.05), and improved the immune organ index to varying degrees. It also significantly improved pH reduction, drip loss, and pressure loss of breast muscle and leg muscle (<i>p</i> < 0.05). Furthermore, it significantly improved immune and antioxidant functions including decreased MDA content of serum (<i>p</i> < 0.01), increased GSH-Px content (<i>p</i> < 0.01), IgG, IgA, and C4 contents (<i>p</i> < 0.05), and increased expression of IL-2 and IFN-γ (<i>p</i> < 0.01). Additionally, the mechanism by which fibrous roots improve immune function in broilers was explored using network pharmacology and molecular docking technology. Network pharmacology and molecular docking revealed that flavonoids such as baicalein, 4′,5-Dihydroxyflavone, 5,7-dihydroxy-6,8-dimethyl-3-(4′-hydroxybenzyl)-chroman-4-one, and 5,7-dihydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-6,8-dimethyl-chroman-4-one were key components that enhanced immune function through the MAPK1 and other key targets involved in regulating the MAPK signaling pathway. From the findings, it can be concluded that incorporating <i>P. cyrtonema</i> Hua fibrous root as a natural feed supplement and growth promoter in broiler diets had a positive impact on bird health and performance. |
| first_indexed | 2024-03-09T17:04:16Z |
| format | Article |
| id | doaj.art-2fbe9f2b87a145d787d444543c122c80 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T17:04:16Z |
| publishDate | 2023-11-01 |
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| series | Antibiotics |
| spelling | doaj.art-2fbe9f2b87a145d787d444543c122c802023-11-24T14:25:24ZengMDPI AGAntibiotics2079-63822023-11-011211162710.3390/antibiotics12111627Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered BroilersTianlu Zhang0Dong Zhou1Miaofen Chen2Hui Zou3Qi Tang4Ying Lu5Yajie Zheng6College of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Animal Medicine, Hunan Agricultural University, Changsha 410128, ChinaYipuyuan Huangjing Technology Co., Ltd., Xinhua 417600, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaCollege of Horticulture, Hunan Agricultural University, Changsha 410128, ChinaThis study was designed to evaluate the effects of different doses of the fibrous roots of <i>Polygonatum cyrtonema</i> Hua on the growth performance, slaughter parameters, meat quality, immune function, cytokines, antioxidant capacity, and intestinal morphology of white-feathered broilers. Also, the mechanism to improve immune functions of broilers was explored through network pharmacology and molecular docking technology. A total of 360 AA-white-feathered broilers were randomly divided into six groups (not separated by sex), with six repetitions per group (<i>n</i> = 10). The groups were as follows: basal diet (CON group), basal diet supplemented with 300 mg/kg aureomycin (ANT group), basal diet supplemented with 2%, 3%, and 4% fibrous root raw powder (LD, MD, and HD group), or basal diet supplemented with 3% fibrous root processed powder (PR group), in a 42-day experiment. The dietary inclusion of <i>P. cyrtonema</i> fibrous roots increased slaughter performance (<i>p</i> < 0.05), reduced the fat rate (<i>p</i> < 0.05), improved intestinal morphology (<i>p</i> < 0.05), and improved the immune organ index to varying degrees. It also significantly improved pH reduction, drip loss, and pressure loss of breast muscle and leg muscle (<i>p</i> < 0.05). Furthermore, it significantly improved immune and antioxidant functions including decreased MDA content of serum (<i>p</i> < 0.01), increased GSH-Px content (<i>p</i> < 0.01), IgG, IgA, and C4 contents (<i>p</i> < 0.05), and increased expression of IL-2 and IFN-γ (<i>p</i> < 0.01). Additionally, the mechanism by which fibrous roots improve immune function in broilers was explored using network pharmacology and molecular docking technology. Network pharmacology and molecular docking revealed that flavonoids such as baicalein, 4′,5-Dihydroxyflavone, 5,7-dihydroxy-6,8-dimethyl-3-(4′-hydroxybenzyl)-chroman-4-one, and 5,7-dihydroxy-3-(2′-hydroxy-4′-methoxybenzyl)-6,8-dimethyl-chroman-4-one were key components that enhanced immune function through the MAPK1 and other key targets involved in regulating the MAPK signaling pathway. From the findings, it can be concluded that incorporating <i>P. cyrtonema</i> Hua fibrous root as a natural feed supplement and growth promoter in broiler diets had a positive impact on bird health and performance.https://www.mdpi.com/2079-6382/12/11/1627fibrous root of <i>Polygonatum cyrtonema</i> Huaantibiotic alternativegrowth performanceimmune functionwhite-feathered broiler |
| spellingShingle | Tianlu Zhang Dong Zhou Miaofen Chen Hui Zou Qi Tang Ying Lu Yajie Zheng Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers Antibiotics fibrous root of <i>Polygonatum cyrtonema</i> Hua antibiotic alternative growth performance immune function white-feathered broiler |
| title | Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers |
| title_full | Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers |
| title_fullStr | Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers |
| title_full_unstemmed | Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers |
| title_short | Effects of the Fibrous Root of <i>Polygonatum cyrtonema</i> Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers |
| title_sort | effects of the fibrous root of i polygonatum cyrtonema i hua on growth performance meat quality immunity antioxidant capacity and intestinal morphology of white feathered broilers |
| topic | fibrous root of <i>Polygonatum cyrtonema</i> Hua antibiotic alternative growth performance immune function white-feathered broiler |
| url | https://www.mdpi.com/2079-6382/12/11/1627 |
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