A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates
Abstract Although sucrose is widely administered to hospitalized infants for single painful procedures, total sucrose volume during the entire neonatal intensive care unit (NICU) stay and associated adverse events are unknown. In a longitudinal observation study, we aimed to quantify and contextuali...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Paediatric & Neonatal Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pne2.12114 |
| _version_ | 1797257869810204672 |
|---|---|
| author | Mariana Bueno Marilyn Ballantyne Marsha Campbell‐Yeo Carole Estabrooks Sharyn Gibbins Denise Harrison Carol McNair Shirine Riahi Janet Squires Anne Synnes Anna Taddio Charles Victor Janet Yamada Bonnie Stevens |
| author_facet | Mariana Bueno Marilyn Ballantyne Marsha Campbell‐Yeo Carole Estabrooks Sharyn Gibbins Denise Harrison Carol McNair Shirine Riahi Janet Squires Anne Synnes Anna Taddio Charles Victor Janet Yamada Bonnie Stevens |
| author_sort | Mariana Bueno |
| collection | DOAJ |
| description | Abstract Although sucrose is widely administered to hospitalized infants for single painful procedures, total sucrose volume during the entire neonatal intensive care unit (NICU) stay and associated adverse events are unknown. In a longitudinal observation study, we aimed to quantify and contextualize sucrose administration during the NICU stay. Specifically, we investigated the frequency, nature, and severity of painful procedures; proportion of procedures where neonates received sucrose; total volume of sucrose administered for painful procedures; and incidence and type of adverse events. Neonates <32 weeks gestational age at birth and <10 days of life were recruited from four Canadian tertiary NICUs. Daily chart reviews of documented painful procedures, sucrose administration, and any associated adverse events were undertaken. One hundred sixty‐eight neonates underwent a total of 9093 skin‐breaking procedures (mean 54.1 [±65.2] procedures/neonate or 1.1 [±0.9] procedures/day/neonate) during an average NICU stay of 45.9 (±31.4) days. Pain severity was recorded for 5399/9093 (59.4%) of the painful procedures; the majority (5051 [93.5%]) were heel lances of moderate pain intensity. Sucrose was administered for 7839/9093 (86.2%) of painful procedures. The total average sucrose volume was 5.5 (±5.4) mL/neonate or 0.11 (±0.08) mL/neonate/day. Infants experienced an average of 7.9 (±12.7) minor adverse events associated with pain and/or sucrose administration that resolved without intervention. The total number of painful procedures, sucrose volume, and incidence of adverse events throughout the NICU stay were described addressing an important knowledge gap in neonatal pain. These data provide a baseline for examining the association between total sucrose volume during NICU stay and research on longer‐term behavioral and neurodevelopmental outcomes. |
| first_indexed | 2024-04-24T22:44:30Z |
| format | Article |
| id | doaj.art-2fbef68c3a8b476ea6a2f9332e9f128b |
| institution | Directory Open Access Journal |
| issn | 2637-3807 |
| language | English |
| last_indexed | 2024-04-24T22:44:30Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Paediatric & Neonatal Pain |
| spelling | doaj.art-2fbef68c3a8b476ea6a2f9332e9f128b2024-03-18T16:19:21ZengWileyPaediatric & Neonatal Pain2637-38072024-03-0161101810.1002/pne2.12114A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonatesMariana Bueno0Marilyn Ballantyne1Marsha Campbell‐Yeo2Carole Estabrooks3Sharyn Gibbins4Denise Harrison5Carol McNair6Shirine Riahi7Janet Squires8Anne Synnes9Anna Taddio10Charles Victor11Janet Yamada12Bonnie Stevens13The Hospital for Sick Children Toronto Ontario CanadaUniversity of Toronto Toronto Ontario CanadaDalhousie University Halifax Nova Scotia CanadaUniversity of Alberta Edmonton Alberta CanadaTrillium Health Partners Mississauga Ontario CanadaUniversity of Melbourne Melbourne Victoria AustraliaThe Hospital for Sick Children Toronto Ontario CanadaThe Hospital for Sick Children Toronto Ontario CanadaUniversity of Ottawa Ottawa Ontario CanadaUniversity of British Columbia Vancouver British Columbia CanadaThe Hospital for Sick Children Toronto Ontario CanadaUniversity of Toronto Toronto Ontario CanadaToronto Metropolitan University Toronto Ontario CanadaThe Hospital for Sick Children Toronto Ontario CanadaAbstract Although sucrose is widely administered to hospitalized infants for single painful procedures, total sucrose volume during the entire neonatal intensive care unit (NICU) stay and associated adverse events are unknown. In a longitudinal observation study, we aimed to quantify and contextualize sucrose administration during the NICU stay. Specifically, we investigated the frequency, nature, and severity of painful procedures; proportion of procedures where neonates received sucrose; total volume of sucrose administered for painful procedures; and incidence and type of adverse events. Neonates <32 weeks gestational age at birth and <10 days of life were recruited from four Canadian tertiary NICUs. Daily chart reviews of documented painful procedures, sucrose administration, and any associated adverse events were undertaken. One hundred sixty‐eight neonates underwent a total of 9093 skin‐breaking procedures (mean 54.1 [±65.2] procedures/neonate or 1.1 [±0.9] procedures/day/neonate) during an average NICU stay of 45.9 (±31.4) days. Pain severity was recorded for 5399/9093 (59.4%) of the painful procedures; the majority (5051 [93.5%]) were heel lances of moderate pain intensity. Sucrose was administered for 7839/9093 (86.2%) of painful procedures. The total average sucrose volume was 5.5 (±5.4) mL/neonate or 0.11 (±0.08) mL/neonate/day. Infants experienced an average of 7.9 (±12.7) minor adverse events associated with pain and/or sucrose administration that resolved without intervention. The total number of painful procedures, sucrose volume, and incidence of adverse events throughout the NICU stay were described addressing an important knowledge gap in neonatal pain. These data provide a baseline for examining the association between total sucrose volume during NICU stay and research on longer‐term behavioral and neurodevelopmental outcomes.https://doi.org/10.1002/pne2.12114analgesiainfantintensive care unitsneonatalnewbornpain |
| spellingShingle | Mariana Bueno Marilyn Ballantyne Marsha Campbell‐Yeo Carole Estabrooks Sharyn Gibbins Denise Harrison Carol McNair Shirine Riahi Janet Squires Anne Synnes Anna Taddio Charles Victor Janet Yamada Bonnie Stevens A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates Paediatric & Neonatal Pain analgesia infant intensive care units neonatal newborn pain |
| title | A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates |
| title_full | A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates |
| title_fullStr | A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates |
| title_full_unstemmed | A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates |
| title_short | A longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates |
| title_sort | longitudinal observational study on the epidemiology of painful procedures and sucrose administration in hospitalized preterm neonates |
| topic | analgesia infant intensive care units neonatal newborn pain |
| url | https://doi.org/10.1002/pne2.12114 |
| work_keys_str_mv | AT marianabueno alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT marilynballantyne alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT marshacampbellyeo alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT caroleestabrooks alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT sharyngibbins alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT deniseharrison alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT carolmcnair alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT shirineriahi alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT janetsquires alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT annesynnes alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT annataddio alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT charlesvictor alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT janetyamada alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT bonniestevens alongitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT marianabueno longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT marilynballantyne longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT marshacampbellyeo longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT caroleestabrooks longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT sharyngibbins longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT deniseharrison longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT carolmcnair longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT shirineriahi longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT janetsquires longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT annesynnes longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT annataddio longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT charlesvictor longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT janetyamada longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates AT bonniestevens longitudinalobservationalstudyontheepidemiologyofpainfulproceduresandsucroseadministrationinhospitalizedpretermneonates |