RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response.

RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response.

The heat shock response (HSR) is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness. Cells that fail to activate or maintain this protective response are hypersensitive to proteotoxic stress. The HSR is...

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Bibliographic Details
Main Authors: Roelien A M Meijering, Marit Wiersma, Denise M S van Marion, Deli Zhang, Femke Hoogstra-Berends, Anne-Jan Dijkhuis, Martina Schmidt, Thomas Wieland, Harm H Kampinga, Robert H Henning, Bianca J J M Brundel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4508109?pdf=render

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