Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication through EV-encapsulated informative content, including proteins, lipids, and nucleic acids. Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal ability der...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/12/6480 |
| _version_ | 1797486554643431424 |
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| author | Yasunari Matsuzaka Ryu Yashiro |
| author_facet | Yasunari Matsuzaka Ryu Yashiro |
| author_sort | Yasunari Matsuzaka |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication through EV-encapsulated informative content, including proteins, lipids, and nucleic acids. Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal ability derived from bone marrow, fat, umbilical cord, menstruation blood, pulp, etc., which they use to induce tissue regeneration by their direct recruitment into injured tissues, including the heart, liver, lung, kidney, etc., or secreting factors, such as <i>vascular endothelial growth factor</i> or insulin-like growth factor. Recently, MSC-derived EVs have been shown to have regenerative effects against various diseases, partially due to the post-transcriptional regulation of target genes by miRNAs. Furthermore, EVs have garnered attention as novel drug delivery systems, because they can specially encapsulate various target molecules. In this review, we summarize the regenerative effects and molecular mechanisms of MSC-derived EVs. |
| first_indexed | 2024-03-09T23:35:48Z |
| format | Article |
| id | doaj.art-2fc1ded930ef4d89a93c9f4f3bfd51d8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:35:48Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2fc1ded930ef4d89a93c9f4f3bfd51d82023-11-23T17:01:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312648010.3390/ijms23126480Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative MedicineYasunari Matsuzaka0Ryu Yashiro1Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, University of Tokyo, Minato-ku 108-8639, Tokyo, JapanAdministrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira 187-8551, Tokyo, JapanExtracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication through EV-encapsulated informative content, including proteins, lipids, and nucleic acids. Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal ability derived from bone marrow, fat, umbilical cord, menstruation blood, pulp, etc., which they use to induce tissue regeneration by their direct recruitment into injured tissues, including the heart, liver, lung, kidney, etc., or secreting factors, such as <i>vascular endothelial growth factor</i> or insulin-like growth factor. Recently, MSC-derived EVs have been shown to have regenerative effects against various diseases, partially due to the post-transcriptional regulation of target genes by miRNAs. Furthermore, EVs have garnered attention as novel drug delivery systems, because they can specially encapsulate various target molecules. In this review, we summarize the regenerative effects and molecular mechanisms of MSC-derived EVs.https://www.mdpi.com/1422-0067/23/12/6480drug deliveryexosomesextracellular vesicleslipid nanoparticlemesenchymal stem cellregenerative medicine |
| spellingShingle | Yasunari Matsuzaka Ryu Yashiro Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine International Journal of Molecular Sciences drug delivery exosomes extracellular vesicles lipid nanoparticle mesenchymal stem cell regenerative medicine |
| title | Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine |
| title_full | Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine |
| title_fullStr | Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine |
| title_full_unstemmed | Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine |
| title_short | Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine |
| title_sort | therapeutic strategy of mesenchymal stem cell derived extracellular vesicles as regenerative medicine |
| topic | drug delivery exosomes extracellular vesicles lipid nanoparticle mesenchymal stem cell regenerative medicine |
| url | https://www.mdpi.com/1422-0067/23/12/6480 |
| work_keys_str_mv | AT yasunarimatsuzaka therapeuticstrategyofmesenchymalstemcellderivedextracellularvesiclesasregenerativemedicine AT ryuyashiro therapeuticstrategyofmesenchymalstemcellderivedextracellularvesiclesasregenerativemedicine |