Systemic bevacizumab for recurrent respiratory papillomatosis. A case series
AbstractRecurrent respiratory papillomatosis (RRP) is a human papilloma virus (HPV) 6/11 related, predominantly histologically benign neoplasm of the upper and lower airway affecting both younger and older patients. Though potentially declining due to HPV vaccination RRP is still challenging in mana...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Acta Oto-Laryngologica Case Reports |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/23772484.2023.2194533 |
| _version_ | 1797245399803625472 |
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| author | Kristine Grubbe Gregersen Jeppe Friborg Claus Andrup Kristensen Kristian Hveysel Bork |
| author_facet | Kristine Grubbe Gregersen Jeppe Friborg Claus Andrup Kristensen Kristian Hveysel Bork |
| author_sort | Kristine Grubbe Gregersen |
| collection | DOAJ |
| description | AbstractRecurrent respiratory papillomatosis (RRP) is a human papilloma virus (HPV) 6/11 related, predominantly histologically benign neoplasm of the upper and lower airway affecting both younger and older patients. Though potentially declining due to HPV vaccination RRP is still challenging in management and a significant cause of affected quality of life. Systemic bevacizumab has shown efficacy for aggressive disease in other case series in juvenile-onset RRP (JORRP) as in adult-onset RRP (AORRP). We present five consecutive patients with AORRP treated with systemic bevacizumab for aggressive laryngeal and tracheal papillomatosis. Adding to the findings of previous reports we show that systemic bevacizumab treatment could have positive influence on aggressive AORRP without pulmonary spread with manageable side effects. |
| first_indexed | 2024-03-08T19:13:19Z |
| format | Article |
| id | doaj.art-2fc219deaf9242b79d4383530c41f077 |
| institution | Directory Open Access Journal |
| issn | 2377-2484 |
| language | English |
| last_indexed | 2024-04-24T19:26:18Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Acta Oto-Laryngologica Case Reports |
| spelling | doaj.art-2fc219deaf9242b79d4383530c41f0772024-03-25T14:56:39ZengTaylor & Francis GroupActa Oto-Laryngologica Case Reports2377-24842023-12-0181475310.1080/23772484.2023.2194533Systemic bevacizumab for recurrent respiratory papillomatosis. A case seriesKristine Grubbe Gregersen0Jeppe Friborg1Claus Andrup Kristensen2Kristian Hveysel Bork3Department of Otorhinolaryngology, Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Oncology, Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Oncology, Rigshospitalet, Copenhagen, DenmarkDepartment of Otorhinolaryngology, Rigshospitalet, Copenhagen, DenmarkAbstractRecurrent respiratory papillomatosis (RRP) is a human papilloma virus (HPV) 6/11 related, predominantly histologically benign neoplasm of the upper and lower airway affecting both younger and older patients. Though potentially declining due to HPV vaccination RRP is still challenging in management and a significant cause of affected quality of life. Systemic bevacizumab has shown efficacy for aggressive disease in other case series in juvenile-onset RRP (JORRP) as in adult-onset RRP (AORRP). We present five consecutive patients with AORRP treated with systemic bevacizumab for aggressive laryngeal and tracheal papillomatosis. Adding to the findings of previous reports we show that systemic bevacizumab treatment could have positive influence on aggressive AORRP without pulmonary spread with manageable side effects.https://www.tandfonline.com/doi/10.1080/23772484.2023.2194533Respiratory papillomatosisbevacizumabsystemiccase series |
| spellingShingle | Kristine Grubbe Gregersen Jeppe Friborg Claus Andrup Kristensen Kristian Hveysel Bork Systemic bevacizumab for recurrent respiratory papillomatosis. A case series Acta Oto-Laryngologica Case Reports Respiratory papillomatosis bevacizumab systemic case series |
| title | Systemic bevacizumab for recurrent respiratory papillomatosis. A case series |
| title_full | Systemic bevacizumab for recurrent respiratory papillomatosis. A case series |
| title_fullStr | Systemic bevacizumab for recurrent respiratory papillomatosis. A case series |
| title_full_unstemmed | Systemic bevacizumab for recurrent respiratory papillomatosis. A case series |
| title_short | Systemic bevacizumab for recurrent respiratory papillomatosis. A case series |
| title_sort | systemic bevacizumab for recurrent respiratory papillomatosis a case series |
| topic | Respiratory papillomatosis bevacizumab systemic case series |
| url | https://www.tandfonline.com/doi/10.1080/23772484.2023.2194533 |
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