Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population

Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population

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Introduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matchi...

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Bibliographic Details
Main Authors: Andisheh Ghashghaie, Kamran Alimoghaddam, Mohammad Reza Ostadali, Hamid-o-allah Ghaffari, L Khansari, M Sadraee, E Mirrasekhian, Iranna Mohyedin, F Raoofi, Z Noori, H Yaghmaian, H Eshaghi, Ardeshir Ghavamzadeh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2009-06-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
HLA
Cord Blood
GvHD
Frequency Transplantation
Donor
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/211
Description
Summary:Introduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matching unrelated donors and recipients for HLA-A, -B and -DRB1 loci is a prediction for an improved outcome. Methods and materials: HLA-A and -B of six hundred Iranian cord blood samples were typed by PCR-SSP method and the frequency of loci were estimated. Results: The most frequent alleles were A*02(18.16), A*24(16.41), B*35(21.66) and B*51(13.35), respectively. Discussion: Our HLA typing data show similarity between neighbor and related countries and Caucasians. Identifying HLA alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation.
ISSN:2008-2207

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