Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population
Introduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matchi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2009-06-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/211 |
| _version_ | 1797707977069690880 |
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| author | Andisheh Ghashghaie Kamran Alimoghaddam Mohammad Reza Ostadali Hamid-o-allah Ghaffari L Khansari M Sadraee E Mirrasekhian Iranna Mohyedin F Raoofi Z Noori H Yaghmaian H Eshaghi Ardeshir Ghavamzadeh |
| author_facet | Andisheh Ghashghaie Kamran Alimoghaddam Mohammad Reza Ostadali Hamid-o-allah Ghaffari L Khansari M Sadraee E Mirrasekhian Iranna Mohyedin F Raoofi Z Noori H Yaghmaian H Eshaghi Ardeshir Ghavamzadeh |
| author_sort | Andisheh Ghashghaie |
| collection | DOAJ |
| description | Introduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matching unrelated donors and recipients for HLA-A, -B and -DRB1 loci is a prediction for an improved outcome.
Methods and materials: HLA-A and -B of six hundred Iranian cord blood samples were typed by PCR-SSP method and the frequency of loci were estimated.
Results: The most frequent alleles were A*02(18.16), A*24(16.41), B*35(21.66) and B*51(13.35), respectively.
Discussion: Our HLA typing data show similarity between neighbor and related countries and Caucasians. Identifying HLA alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation. |
| first_indexed | 2024-03-12T06:14:29Z |
| format | Article |
| id | doaj.art-2fc22b8ffc1b4bf18477dbdf93cd5c3c |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T06:14:29Z |
| publishDate | 2009-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-2fc22b8ffc1b4bf18477dbdf93cd5c3c2023-09-03T02:42:25ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072009-06-0132Allele Frequencies of HLA Class-I Loci in the Normal Iranian PopulationAndisheh Ghashghaie0Kamran Alimoghaddam1Mohammad Reza Ostadali2Hamid-o-allah Ghaffari3L Khansari4M Sadraee5E Mirrasekhian6Iranna Mohyedin7F Raoofi8Z Noori9H Yaghmaian10H Eshaghi11Ardeshir Ghavamzadeh12Hematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranHematology- Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Dr. Shariati Hospital, Tehran, IranIntroduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matching unrelated donors and recipients for HLA-A, -B and -DRB1 loci is a prediction for an improved outcome. Methods and materials: HLA-A and -B of six hundred Iranian cord blood samples were typed by PCR-SSP method and the frequency of loci were estimated. Results: The most frequent alleles were A*02(18.16), A*24(16.41), B*35(21.66) and B*51(13.35), respectively. Discussion: Our HLA typing data show similarity between neighbor and related countries and Caucasians. Identifying HLA alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/211HLACord BloodGvHDFrequency TransplantationDonor |
| spellingShingle | Andisheh Ghashghaie Kamran Alimoghaddam Mohammad Reza Ostadali Hamid-o-allah Ghaffari L Khansari M Sadraee E Mirrasekhian Iranna Mohyedin F Raoofi Z Noori H Yaghmaian H Eshaghi Ardeshir Ghavamzadeh Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population International Journal of Hematology-Oncology and Stem Cell Research HLA Cord Blood GvHD Frequency Transplantation Donor |
| title | Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population |
| title_full | Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population |
| title_fullStr | Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population |
| title_full_unstemmed | Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population |
| title_short | Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population |
| title_sort | allele frequencies of hla class i loci in the normal iranian population |
| topic | HLA Cord Blood GvHD Frequency Transplantation Donor |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/211 |
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