The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery mediates the membrane fission step that completes cytokinetic abscission and separates dividing cells. Filaments composed of ESCRT-III subunits constrict membranes of the intercellular bridge midbody to the abscission point. Th...

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Bibliographic Details
Main Authors: Elliott L Paine, Jack J Skalicky, Frank G Whitby, Douglas R Mackay, Katharine S Ullman, Christopher P Hill, Wesley I Sundquist
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
cytokinesis
ESCRT-III
abscission
NoCut Checkpoint
Online Access:https://elifesciences.org/articles/84515

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