Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility
Abstract Abnormal cyclic motor pattern (CMP) activity is implicated in colonic dysfunction, but the only tool to evaluate CMP activity, high-resolution colonic manometry (HRCM), remains expensive and not widely accessible. This study aimed to validate body surface colonic mapping (BSCM) through dire...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-54429-7 |
| _version_ | 1827327885548978176 |
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| author | Sean H. B. Seo Cameron I. Wells Tully Dickson David Rowbotham Armen Gharibans Stefan Calder Ian Bissett Greg O’Grady Jonathan C. Erickson |
| author_facet | Sean H. B. Seo Cameron I. Wells Tully Dickson David Rowbotham Armen Gharibans Stefan Calder Ian Bissett Greg O’Grady Jonathan C. Erickson |
| author_sort | Sean H. B. Seo |
| collection | DOAJ |
| description | Abstract Abnormal cyclic motor pattern (CMP) activity is implicated in colonic dysfunction, but the only tool to evaluate CMP activity, high-resolution colonic manometry (HRCM), remains expensive and not widely accessible. This study aimed to validate body surface colonic mapping (BSCM) through direct correlation with HRCM. Synchronous meal-test recordings were performed in asymptomatic participants with intact colons. A signal processing method for BSCM was developed to detect CMPs. Quantitative temporal analysis was performed comparing the meal responses and motility indices (MI). Spatial heat maps were also compared. Post-study questionnaires evaluated participants’ preference and comfort/distress experienced from either test. 11 participants were recruited and 7 had successful synchronous recordings (5 females/2 males; median age: 50 years [range 38–63]). The best-correlating MI temporal analyses achieved a high degree of agreement (median Pearson correlation coefficient (Rp) value: 0.69; range 0.47–0.77). HRCM and BSCM meal response start and end times (Rp = 0.998 and 0.83; both p < 0.05) and durations (Rp = 0.85; p = 0.03) were similar. Heat maps demonstrated good spatial agreement. BSCM is the first non-invasive method to be validated by demonstrating a direct spatio-temporal correlation to manometry in evaluating colonic motility. |
| first_indexed | 2024-03-07T15:09:54Z |
| format | Article |
| id | doaj.art-2fc61f93ba014975a7bdaa027cd8e1ce |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:09:54Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-2fc61f93ba014975a7bdaa027cd8e1ce2024-03-05T18:43:11ZengNature PortfolioScientific Reports2045-23222024-02-0114111510.1038/s41598-024-54429-7Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motilitySean H. B. Seo0Cameron I. Wells1Tully Dickson2David Rowbotham3Armen Gharibans4Stefan Calder5Ian Bissett6Greg O’Grady7Jonathan C. Erickson8Department of Surgery, The University of AucklandDepartment of Surgery, The University of AucklandDepartment of Surgery, The University of AucklandDepartment of Gastroenterology, Auckland City Hospital, Te Whatu Ora Health New ZealandAlimetry LtdAlimetry LtdDepartment of Surgery, The University of AucklandDepartment of Surgery, The University of AucklandAlimetry LtdAbstract Abnormal cyclic motor pattern (CMP) activity is implicated in colonic dysfunction, but the only tool to evaluate CMP activity, high-resolution colonic manometry (HRCM), remains expensive and not widely accessible. This study aimed to validate body surface colonic mapping (BSCM) through direct correlation with HRCM. Synchronous meal-test recordings were performed in asymptomatic participants with intact colons. A signal processing method for BSCM was developed to detect CMPs. Quantitative temporal analysis was performed comparing the meal responses and motility indices (MI). Spatial heat maps were also compared. Post-study questionnaires evaluated participants’ preference and comfort/distress experienced from either test. 11 participants were recruited and 7 had successful synchronous recordings (5 females/2 males; median age: 50 years [range 38–63]). The best-correlating MI temporal analyses achieved a high degree of agreement (median Pearson correlation coefficient (Rp) value: 0.69; range 0.47–0.77). HRCM and BSCM meal response start and end times (Rp = 0.998 and 0.83; both p < 0.05) and durations (Rp = 0.85; p = 0.03) were similar. Heat maps demonstrated good spatial agreement. BSCM is the first non-invasive method to be validated by demonstrating a direct spatio-temporal correlation to manometry in evaluating colonic motility.https://doi.org/10.1038/s41598-024-54429-7 |
| spellingShingle | Sean H. B. Seo Cameron I. Wells Tully Dickson David Rowbotham Armen Gharibans Stefan Calder Ian Bissett Greg O’Grady Jonathan C. Erickson Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility Scientific Reports |
| title | Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility |
| title_full | Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility |
| title_fullStr | Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility |
| title_full_unstemmed | Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility |
| title_short | Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility |
| title_sort | validation of body surface colonic mapping bscm against high resolution colonic manometry for evaluation of colonic motility |
| url | https://doi.org/10.1038/s41598-024-54429-7 |
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