Screening of NKX2.5 gene in Moroccan Tetralogy of Fallot (TOF) patients: worldwide mutation rate comparisons show a significant association between R25C variant and TOF phenotype

Screening of NKX2.5 gene in Moroccan Tetralogy of Fallot (TOF) patients: worldwide mutation rate comparisons show a significant association between R25C variant and TOF phenotype

Abstract Background Tetralogy of Fallot is the most prevalent cyanotic congenital heart disease, occurring in 1/3 600 live births. This disorder comprises ventricular septal defect, right ventricular outflow obstruction, over-riding aorta, and right ventricular hypertrophy. The present study aims to...

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Bibliographic Details
Main Authors: Ihssane EL Bouchikhi, Khadija Belhassan, Fatima Zohra Moufid, Laila Bouguenouch, Imane Samri, Mohammed Iraqui Houssaïni, Karim Ouldim, Samir Atmani
Format: Article
Language:English
Published: SpringerOpen 2021-03-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Tetralogy of Fallot (TOF)
NKX2.5
R25C mutation
Genetic screening
Moroccan population
Mutation rate
Online Access:https://doi.org/10.1186/s43042-021-00136-1

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