An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites
Chromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. In order to identify which CFSs are influential or signific...
| 主要な著者: | , , , , |
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
Taylor & Francis
2024-12-01
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| シリーズ: | Research in Statistics |
| 主題: | |
| オンライン･アクセス: | https://www.tandfonline.com/doi/10.1080/27684520.2024.2331110 |
| _version_ | 1826951613160357888 |
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| author | Giovani L. Silva Inês J. Sequeira D. Prata Gomes José Rueff Aldina Brás |
| author_facet | Giovani L. Silva Inês J. Sequeira D. Prata Gomes José Rueff Aldina Brás |
| author_sort | Giovani L. Silva |
| collection | DOAJ |
| description | Chromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. In order to identify which CFSs are influential or significant in the occurrence of deletions and duplications (chromosomal constitutional imbalances), we propose a logistic regression analysis for the CFS data set, since the underlying response variable is categorical, specifically binary (deletion or duplication). Some results are presented here as an informative preliminary contribution to understand the frailty of these CFS in increasing/decreasing of the deletion odds. This study has implications for our comprehension of human pathogenesis. |
| first_indexed | 2024-04-24T16:34:43Z |
| format | Article |
| id | doaj.art-2fc6c9184e1b48a5843ebac669ebb961 |
| institution | Directory Open Access Journal |
| issn | 2768-4520 |
| language | English |
| last_indexed | 2025-02-17T22:52:41Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Research in Statistics |
| spelling | doaj.art-2fc6c9184e1b48a5843ebac669ebb9612024-12-02T19:00:47ZengTaylor & FrancisResearch in Statistics2768-45202024-12-012110.1080/27684520.2024.2331110An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sitesGiovani L. Silva0Inês J. Sequeira1D. Prata Gomes2José Rueff3Aldina Brás4Centre of Statistics and its Applications (CEAUL) and Dep. Mathematics, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, PortugalCenter for Mathematics and Applications (NOVA Math) and Department of Mathematics, NOVA FCT, Lisbon, PortugalCenter for Mathematics and Applications (NOVA Math) and Department of Mathematics, NOVA FCT, Lisbon, PortugalTOXOMICS, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, PortugalTOXOMICS, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, PortugalChromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. In order to identify which CFSs are influential or significant in the occurrence of deletions and duplications (chromosomal constitutional imbalances), we propose a logistic regression analysis for the CFS data set, since the underlying response variable is categorical, specifically binary (deletion or duplication). Some results are presented here as an informative preliminary contribution to understand the frailty of these CFS in increasing/decreasing of the deletion odds. This study has implications for our comprehension of human pathogenesis.https://www.tandfonline.com/doi/10.1080/27684520.2024.2331110Chromosomal fragile sitesdeletionsduplicationslogistic regression model |
| spellingShingle | Giovani L. Silva Inês J. Sequeira D. Prata Gomes José Rueff Aldina Brás An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites Research in Statistics Chromosomal fragile sites deletions duplications logistic regression model |
| title | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_full | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_fullStr | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_full_unstemmed | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_short | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_sort | application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| topic | Chromosomal fragile sites deletions duplications logistic regression model |
| url | https://www.tandfonline.com/doi/10.1080/27684520.2024.2331110 |
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