Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism
Introduction Subclinical hyperthyroidism (SHT) is an endocrine disorder that is associated with abnormalities in heart structure and function. Oxidative stress plays an important role in the pathophysiology of cardiac disorders caused by SHT. Portulaca oleracea (P. Oleracea) is a herbaceous plant wi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-10-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2022.2112209 |
| _version_ | 1797681070470070272 |
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| author | Mousa- al-Reza Hadjzadeh Hadi Khodadadi Farzaneh Sohrabi Mahdiyeh Hedayati-Moghadam Atieh Ghorbani Sara Hosseinian |
| author_facet | Mousa- al-Reza Hadjzadeh Hadi Khodadadi Farzaneh Sohrabi Mahdiyeh Hedayati-Moghadam Atieh Ghorbani Sara Hosseinian |
| author_sort | Mousa- al-Reza Hadjzadeh |
| collection | DOAJ |
| description | Introduction Subclinical hyperthyroidism (SHT) is an endocrine disorder that is associated with abnormalities in heart structure and function. Oxidative stress plays an important role in the pathophysiology of cardiac disorders caused by SHT. Portulaca oleracea (P. Oleracea) is a herbaceous plant with many pharmacologic effects including antioxidant, and anti-inflammatory properties. In the present study, the effects of Portulaca oleracea and vitamin E on the biochemical, hemodynamic, and functional parameters of the cardiac tissue was studied in rats with subclinical hyperthyroidism. Methods Fifty-six male rats were divided into seven groups: 1-Control group: daily injection of saline, 2-SHT group: daily injection of levothyroxine sodium (LS) (20 µg/kg), 3- T4+Po groups were given LS and P. oleracea (100, 200, and 400 mg/kg in drinking water), 4- the T4+vit E groups received LS and a daily injection of vitamin E (100 and 200 mg/kg). Cardiac index, systolic blood pressure (SBP), also malondialdehyde and total thiol levels were measured in cardiac tissue. Results SBP and maximum dP/dt were significantly increased and minimum dP/dt was significantly decreased in SHT group. In P. oleracea groups, maximum dP/dt were significantly reduced and minimum dP/dt was increased. Malondialdehyde levels and cardiac index in groups receiving vitamin E and P. oleracea were significantly decreased. Maximum dP/dt was decreased in the group receiving LS+vitamin E. Minimum dP/dt was significantly higher in group received LS+ vitamin E. Conclusion This study showed that Portulaca oleracea has a positive effect on cardiac dysfunction caused by subclinical hyperthyroidism. |
| first_indexed | 2024-03-11T23:39:43Z |
| format | Article |
| id | doaj.art-2fc6fd5696244244b1515901eefcab06 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:43Z |
| publishDate | 2022-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-2fc6fd5696244244b1515901eefcab062023-09-19T16:04:08ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062022-10-0144766366910.1080/10641963.2022.21122092112209Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidismMousa- al-Reza Hadjzadeh0Hadi Khodadadi1Farzaneh Sohrabi2Mahdiyeh Hedayati-Moghadam3Atieh Ghorbani4Sara Hosseinian5Mashhad University of Medical SciencesMashhad University of Medical SciencesMashhad University of Medical SciencesStudent Research Committee, Jiroft University of Medical SciencesMashhad University of Medical SciencesMashhad University of Medical SciencesIntroduction Subclinical hyperthyroidism (SHT) is an endocrine disorder that is associated with abnormalities in heart structure and function. Oxidative stress plays an important role in the pathophysiology of cardiac disorders caused by SHT. Portulaca oleracea (P. Oleracea) is a herbaceous plant with many pharmacologic effects including antioxidant, and anti-inflammatory properties. In the present study, the effects of Portulaca oleracea and vitamin E on the biochemical, hemodynamic, and functional parameters of the cardiac tissue was studied in rats with subclinical hyperthyroidism. Methods Fifty-six male rats were divided into seven groups: 1-Control group: daily injection of saline, 2-SHT group: daily injection of levothyroxine sodium (LS) (20 µg/kg), 3- T4+Po groups were given LS and P. oleracea (100, 200, and 400 mg/kg in drinking water), 4- the T4+vit E groups received LS and a daily injection of vitamin E (100 and 200 mg/kg). Cardiac index, systolic blood pressure (SBP), also malondialdehyde and total thiol levels were measured in cardiac tissue. Results SBP and maximum dP/dt were significantly increased and minimum dP/dt was significantly decreased in SHT group. In P. oleracea groups, maximum dP/dt were significantly reduced and minimum dP/dt was increased. Malondialdehyde levels and cardiac index in groups receiving vitamin E and P. oleracea were significantly decreased. Maximum dP/dt was decreased in the group receiving LS+vitamin E. Minimum dP/dt was significantly higher in group received LS+ vitamin E. Conclusion This study showed that Portulaca oleracea has a positive effect on cardiac dysfunction caused by subclinical hyperthyroidism.http://dx.doi.org/10.1080/10641963.2022.2112209portulaca oleraceavitamin eheartoxidative stresssubclinical hyperthyroidism |
| spellingShingle | Mousa- al-Reza Hadjzadeh Hadi Khodadadi Farzaneh Sohrabi Mahdiyeh Hedayati-Moghadam Atieh Ghorbani Sara Hosseinian Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism Clinical and Experimental Hypertension portulaca oleracea vitamin e heart oxidative stress subclinical hyperthyroidism |
| title | Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism |
| title_full | Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism |
| title_fullStr | Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism |
| title_full_unstemmed | Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism |
| title_short | Protective effects of Portulaca oleracea and vitamin E on cardiovascular parameters in rats with subclinical hyperthyroidism |
| title_sort | protective effects of portulaca oleracea and vitamin e on cardiovascular parameters in rats with subclinical hyperthyroidism |
| topic | portulaca oleracea vitamin e heart oxidative stress subclinical hyperthyroidism |
| url | http://dx.doi.org/10.1080/10641963.2022.2112209 |
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