Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome
Purpose Chronic pelvic pain syndrome (CPPS) is treated by use of various protocols. We compared tamsulosin monotherapy with tamsulosin in combination with antibiotics or anti-inflammatory agents and evaluated the efficacy of these treatments in patients with CPPS. Methods Patients (n=107) who were y...
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2011-06-01
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| Series: | International Neurourology Journal |
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| Online Access: | http://www.einj.org/upload/pdf/inj-15-92.pdf |
| _version_ | 1818508661294628864 |
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| author | Tae Hyo Kim Ki Soo Lee Jeong Ho Kim Joon Yeop Jee Young Eun Seo Dong Won Choi Yeul Geun Sung Geun Soo Kong Dong Woo Kim Won Yeol Cho |
| author_facet | Tae Hyo Kim Ki Soo Lee Jeong Ho Kim Joon Yeop Jee Young Eun Seo Dong Won Choi Yeul Geun Sung Geun Soo Kong Dong Woo Kim Won Yeol Cho |
| author_sort | Tae Hyo Kim |
| collection | DOAJ |
| description | Purpose Chronic pelvic pain syndrome (CPPS) is treated by use of various protocols. We compared tamsulosin monotherapy with tamsulosin in combination with antibiotics or anti-inflammatory agents and evaluated the efficacy of these treatments in patients with CPPS. Methods Patients (n=107) who were younger than 55 years and diagnosed with CPPS were randomly assigned to treatment with tamsulosin at 0.2 mg (group A), tamsulosin at 0.2 mg plus anti-inflammatory drugs (group B) or tamsulosin at 0.2 mg plus antibiotics (group C) daily. We applied the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostate Symptom Score (IPSS) to evaluate 100 patients who were treated for 12 weeks (7 withdrew). Scores of the three groups were compared by analysis of variance and we also evaluated subscores, which included pain, voiding and quality of life (QoL). Results All three groups showed statistically significant decreases in NIH-CPSI score, IPSS and subscore scores (P<0.05). There were no statistically significant differences between the groups except for the QoL domain of the IPSS (group A vs. C; P<0.01). Conclusions Tamsulosin monotherapy for 12 weeks was effective for treating patients with CPPS, compared with combination therapy with antibiotics or anti-inflammatory drugs. |
| first_indexed | 2024-12-10T22:35:07Z |
| format | Article |
| id | doaj.art-2fc78804a6894dc39aa281d7fd2ddfb9 |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-10T22:35:07Z |
| publishDate | 2011-06-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-2fc78804a6894dc39aa281d7fd2ddfb92022-12-22T01:30:56ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312011-06-01152929610.5213/inj.2011.15.2.9256Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain SyndromeTae Hyo Kim0Ki Soo Lee1Jeong Ho Kim2Joon Yeop Jee3Young Eun Seo4Dong Won Choi5Yeul Geun Sung6Geun Soo Kong7Dong Woo Kim8Won Yeol Cho9 Department of Urology, Dongnam Inst. Radiological & Medical Sciences, Busan, Korea. Department of Urology, Dongnam Inst. Radiological & Medical Sciences, Busan, Korea. Department of Urology, Dongnam Inst. Radiological & Medical Sciences, Busan, Korea. Department of Urology, Dongnam Inst. Radiological & Medical Sciences, Busan, Korea. Department of Urology, Dongnam Inst. Radiological & Medical Sciences, Busan, Korea. Department of Urology, Youngdo Hospital, Busan, Korea. Department of Urology, Maryknoll Hoapital, Busan, Korea. Department of Urology, Bumin Hospital, Busan, Korea. Department of Urology, Dong Rae Bong Seng Hospital, Busan, Korea. Department of Urology, Dongnam Inst. Radiological & Medical Sciences, Busan, Korea.Purpose Chronic pelvic pain syndrome (CPPS) is treated by use of various protocols. We compared tamsulosin monotherapy with tamsulosin in combination with antibiotics or anti-inflammatory agents and evaluated the efficacy of these treatments in patients with CPPS. Methods Patients (n=107) who were younger than 55 years and diagnosed with CPPS were randomly assigned to treatment with tamsulosin at 0.2 mg (group A), tamsulosin at 0.2 mg plus anti-inflammatory drugs (group B) or tamsulosin at 0.2 mg plus antibiotics (group C) daily. We applied the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostate Symptom Score (IPSS) to evaluate 100 patients who were treated for 12 weeks (7 withdrew). Scores of the three groups were compared by analysis of variance and we also evaluated subscores, which included pain, voiding and quality of life (QoL). Results All three groups showed statistically significant decreases in NIH-CPSI score, IPSS and subscore scores (P<0.05). There were no statistically significant differences between the groups except for the QoL domain of the IPSS (group A vs. C; P<0.01). Conclusions Tamsulosin monotherapy for 12 weeks was effective for treating patients with CPPS, compared with combination therapy with antibiotics or anti-inflammatory drugs.http://www.einj.org/upload/pdf/inj-15-92.pdfChronic Prostatitis with Chronic Pelvic Pain SyndromeTamsulosin |
| spellingShingle | Tae Hyo Kim Ki Soo Lee Jeong Ho Kim Joon Yeop Jee Young Eun Seo Dong Won Choi Yeul Geun Sung Geun Soo Kong Dong Woo Kim Won Yeol Cho Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome International Neurourology Journal Chronic Prostatitis with Chronic Pelvic Pain Syndrome Tamsulosin |
| title | Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome |
| title_full | Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome |
| title_fullStr | Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome |
| title_full_unstemmed | Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome |
| title_short | Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome |
| title_sort | tamsulosin monotherapy versus combination therapy with antibiotics or anti inflammatory agents in the treatment of chronic pelvic pain syndrome |
| topic | Chronic Prostatitis with Chronic Pelvic Pain Syndrome Tamsulosin |
| url | http://www.einj.org/upload/pdf/inj-15-92.pdf |
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