An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats
Diabetes is a metabolic disorder which affects whole body systems including reproductive system. Diabetes is also a contributing factor to infertility. Metformin is one of the most common drugs to control hyperglycemia. In this study, 36 adult Sprague-Dawley female rats (170-210 g) were divided into...
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| Format: | Article |
| Language: | English |
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Urmia University
2012-06-01
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| Series: | Veterinary Research Forum |
| Subjects: | |
| Online Access: | http://www.urmia.ac.ir/vrf/Shared%20Documents/pdf/vol-3%20no-2/79-84%20-%200108.pdf |
| _version_ | 1811304587683954688 |
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| author | Pouya Pournaghi Rajab-Ali Sadrkhanlou Shapour Hasanzadeh Azadeh Foroughi |
| author_facet | Pouya Pournaghi Rajab-Ali Sadrkhanlou Shapour Hasanzadeh Azadeh Foroughi |
| author_sort | Pouya Pournaghi |
| collection | DOAJ |
| description | Diabetes is a metabolic disorder which affects whole body systems including reproductive system. Diabetes is also a contributing factor to infertility. Metformin is one of the most common drugs to control hyperglycemia. In this study, 36 adult Sprague-Dawley female rats (170-210 g) were divided into 3 groups (control, diabetic and diabetic-treated by metformin). In second and third groups, diabetes was induced by streptozotocin injection (45 mg kg-1, IP) and the third group was treated by metformin hydrochloride (100 mg kg-1 day-1, PO) for 8 weeks. Body weights were compared and blood glucose, gonadotropins and sexual hormones were measured. In diabetic group the blood glucose level significantly (P < 0.05) increased in comparison with that of control and metformin-treated diabetic rats. The results also revealed that, in the untreated diabetic rats, the mean body weights and pituitary-gonadal axis hormones were significantly (P < 0.05) reduced in comparison with the control. Although there were significant (P < 0.05) reduction in mean body weights in metformin-treated diabetic rats, reduction in pituitary-gonadal axis hormones was not as sharp as in untreated diabetic rats and only level of progesterone was significantly (P < 0.05) reduced in comparison with the control. The results of this investigation revealed that there was a clear relationship between experimental diabetes with body weight and pituitary-gonadal axis hormones, and treatment with metformin relatively restored diabetic complications. |
| first_indexed | 2024-04-13T08:09:59Z |
| format | Article |
| id | doaj.art-2fc8f3819d7344529bac3bb57a304c1a |
| institution | Directory Open Access Journal |
| issn | 2008-8140 |
| language | English |
| last_indexed | 2024-04-13T08:09:59Z |
| publishDate | 2012-06-01 |
| publisher | Urmia University |
| record_format | Article |
| series | Veterinary Research Forum |
| spelling | doaj.art-2fc8f3819d7344529bac3bb57a304c1a2022-12-22T02:55:01ZengUrmia UniversityVeterinary Research Forum2008-81402012-06-01327984An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female ratsPouya PournaghiRajab-Ali SadrkhanlouShapour HasanzadehAzadeh ForoughiDiabetes is a metabolic disorder which affects whole body systems including reproductive system. Diabetes is also a contributing factor to infertility. Metformin is one of the most common drugs to control hyperglycemia. In this study, 36 adult Sprague-Dawley female rats (170-210 g) were divided into 3 groups (control, diabetic and diabetic-treated by metformin). In second and third groups, diabetes was induced by streptozotocin injection (45 mg kg-1, IP) and the third group was treated by metformin hydrochloride (100 mg kg-1 day-1, PO) for 8 weeks. Body weights were compared and blood glucose, gonadotropins and sexual hormones were measured. In diabetic group the blood glucose level significantly (P < 0.05) increased in comparison with that of control and metformin-treated diabetic rats. The results also revealed that, in the untreated diabetic rats, the mean body weights and pituitary-gonadal axis hormones were significantly (P < 0.05) reduced in comparison with the control. Although there were significant (P < 0.05) reduction in mean body weights in metformin-treated diabetic rats, reduction in pituitary-gonadal axis hormones was not as sharp as in untreated diabetic rats and only level of progesterone was significantly (P < 0.05) reduced in comparison with the control. The results of this investigation revealed that there was a clear relationship between experimental diabetes with body weight and pituitary-gonadal axis hormones, and treatment with metformin relatively restored diabetic complications.http://www.urmia.ac.ir/vrf/Shared%20Documents/pdf/vol-3%20no-2/79-84%20-%200108.pdfDiabetesMetforminBody weightHormoneRat |
| spellingShingle | Pouya Pournaghi Rajab-Ali Sadrkhanlou Shapour Hasanzadeh Azadeh Foroughi An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats Veterinary Research Forum Diabetes Metformin Body weight Hormone Rat |
| title | An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats |
| title_full | An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats |
| title_fullStr | An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats |
| title_full_unstemmed | An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats |
| title_short | An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats |
| title_sort | investigation on body weights blood glucose levels and pituitary gonadal axis hormones in diabetic and metformin treated diabetic female rats |
| topic | Diabetes Metformin Body weight Hormone Rat |
| url | http://www.urmia.ac.ir/vrf/Shared%20Documents/pdf/vol-3%20no-2/79-84%20-%200108.pdf |
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