Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem
Metabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor (TGCT). It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic chemotherapy. In this study, changes in the body composition of patient...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=5;spage=458;epage=462;aulast=Takai |
| _version_ | 1818482311955480576 |
|---|---|
| author | Yuki Takai Sei Naito Hidenori Kanno Atsushi Yamagishi Mayu Yagi Toshihiko Sakurai Hayato Nishida Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya |
| author_facet | Yuki Takai Sei Naito Hidenori Kanno Atsushi Yamagishi Mayu Yagi Toshihiko Sakurai Hayato Nishida Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya |
| author_sort | Yuki Takai |
| collection | DOAJ |
| description | Metabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor (TGCT). It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic chemotherapy. In this study, changes in the body composition of patients over time were quantitatively analyzed up to 24 months after chemotherapy. This study retrospectively analyzed 44 patients with TGCT who underwent chemotherapy at our institution from January 2008 to December 2016. Subcutaneous and visceral fat areas and psoas and skeletal muscle areas were measured by computed tomography before and immediately after chemotherapy as well as 3 months, 6 months, 12 months, and 24 months after chemotherapy. The subcutaneous and visceral fat indices and psoas and skeletal muscle indices were calculated as each area divided by body height squared. The total fat area had already significantly increased 3 months after the initiation of chemotherapy (P = 0.004). However, it did not return to prechemotherapeutic levels even at 24 months after chemotherapy. The skeletal muscle area was significantly decreased at the end of chemotherapy (P < 0.001); however, the value returned to baseline within 12 months. In multivariable analysis, the prechemotherapeutic skeletal muscle index and number of chemotherapy cycles were independently associated with the reduction of skeletal muscle at the end of chemotherapy (P = 0.001 and P = 0.027, respectively). In patients with TGCT, skeletal muscle mass decreased during chemotherapy and recovered within 12 months, whereas fat mass progressively increased from the initiation of chemotherapy until 24 months after chemotherapy. |
| first_indexed | 2024-12-10T11:46:04Z |
| format | Article |
| id | doaj.art-2fcb731241cc45c6baa47e4025dfe8be |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-10T11:46:04Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-2fcb731241cc45c6baa47e4025dfe8be2022-12-22T01:50:05ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622022-01-0124545846210.4103/aja202195Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problemYuki TakaiSei NaitoHidenori KannoAtsushi YamagishiMayu YagiToshihiko SakuraiHayato NishidaTakuya YamanobeTomoyuki KatoNorihiko TsuchiyaMetabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor (TGCT). It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic chemotherapy. In this study, changes in the body composition of patients over time were quantitatively analyzed up to 24 months after chemotherapy. This study retrospectively analyzed 44 patients with TGCT who underwent chemotherapy at our institution from January 2008 to December 2016. Subcutaneous and visceral fat areas and psoas and skeletal muscle areas were measured by computed tomography before and immediately after chemotherapy as well as 3 months, 6 months, 12 months, and 24 months after chemotherapy. The subcutaneous and visceral fat indices and psoas and skeletal muscle indices were calculated as each area divided by body height squared. The total fat area had already significantly increased 3 months after the initiation of chemotherapy (P = 0.004). However, it did not return to prechemotherapeutic levels even at 24 months after chemotherapy. The skeletal muscle area was significantly decreased at the end of chemotherapy (P < 0.001); however, the value returned to baseline within 12 months. In multivariable analysis, the prechemotherapeutic skeletal muscle index and number of chemotherapy cycles were independently associated with the reduction of skeletal muscle at the end of chemotherapy (P = 0.001 and P = 0.027, respectively). In patients with TGCT, skeletal muscle mass decreased during chemotherapy and recovered within 12 months, whereas fat mass progressively increased from the initiation of chemotherapy until 24 months after chemotherapy.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=5;spage=458;epage=462;aulast=Takaibody composition; chemotherapy; obesity; sarcopenia; secondary hypogonadism; testicular cancer |
| spellingShingle | Yuki Takai Sei Naito Hidenori Kanno Atsushi Yamagishi Mayu Yagi Toshihiko Sakurai Hayato Nishida Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem Asian Journal of Andrology body composition; chemotherapy; obesity; sarcopenia; secondary hypogonadism; testicular cancer |
| title | Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem |
| title_full | Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem |
| title_fullStr | Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem |
| title_full_unstemmed | Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem |
| title_short | Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem |
| title_sort | body composition changes following chemotherapy for testicular germ cell tumor obesity is the long term problem |
| topic | body composition; chemotherapy; obesity; sarcopenia; secondary hypogonadism; testicular cancer |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=5;spage=458;epage=462;aulast=Takai |
| work_keys_str_mv | AT yukitakai bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT seinaito bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT hidenorikanno bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT atsushiyamagishi bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT mayuyagi bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT toshihikosakurai bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT hayatonishida bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT takuyayamanobe bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT tomoyukikato bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem AT norihikotsuchiya bodycompositionchangesfollowingchemotherapyfortesticulargermcelltumorobesityisthelongtermproblem |