A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain
Type IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-02-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861318302202 |
| _version_ | 1818311936523108352 |
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| author | Muneyoshi Okada Hideyuki Yamawaki |
| author_facet | Muneyoshi Okada Hideyuki Yamawaki |
| author_sort | Muneyoshi Okada |
| collection | DOAJ |
| description | Type IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin has been widely investigated as a novel target molecule for cancer therapy. The anti-angiogenic effect of canstatin may be also useful for the treatment of ocular neovascularization. Recently, we have demonstrated that canstatin, which is abundantly expressed in the heart tissue, exerts various biological activities in cardiac cells. In rat H9c2 cardiomyoblasts, canstatin inhibits isoproterenol- or hypoxia-induced apoptosis. Canstatin plays an important role in modulating voltage-dependent calcium channel activity in rat cardiomyocytes. Canstatin also regulates various biological functions in rat cardiac fibroblasts and myofibroblasts. The expression of canstatin decreases in the infarcted area after myocardial infarction. This review focuses on a current perspective for the roles of canstatin in tumorigenesis, ocular neovascularization and cardiac pathology. Keywords: Anti-tumor effect, Canstatin, Fibroblasts, Cytoprotective effect, Myocardial infarction |
| first_indexed | 2024-12-13T08:09:53Z |
| format | Article |
| id | doaj.art-2fcd0af8fb724e87920203f51d6aef8f |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-13T08:09:53Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-2fcd0af8fb724e87920203f51d6aef8f2022-12-21T23:54:14ZengElsevierJournal of Pharmacological Sciences1347-86132019-02-0113925964A current perspective of canstatin, a fragment of type IV collagen alpha 2 chainMuneyoshi Okada0Hideyuki Yamawaki1Corresponding author. Fax: +81 176 23 8703.; Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada City, Aomori 034-8628, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada City, Aomori 034-8628, JapanType IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin has been widely investigated as a novel target molecule for cancer therapy. The anti-angiogenic effect of canstatin may be also useful for the treatment of ocular neovascularization. Recently, we have demonstrated that canstatin, which is abundantly expressed in the heart tissue, exerts various biological activities in cardiac cells. In rat H9c2 cardiomyoblasts, canstatin inhibits isoproterenol- or hypoxia-induced apoptosis. Canstatin plays an important role in modulating voltage-dependent calcium channel activity in rat cardiomyocytes. Canstatin also regulates various biological functions in rat cardiac fibroblasts and myofibroblasts. The expression of canstatin decreases in the infarcted area after myocardial infarction. This review focuses on a current perspective for the roles of canstatin in tumorigenesis, ocular neovascularization and cardiac pathology. Keywords: Anti-tumor effect, Canstatin, Fibroblasts, Cytoprotective effect, Myocardial infarctionhttp://www.sciencedirect.com/science/article/pii/S1347861318302202 |
| spellingShingle | Muneyoshi Okada Hideyuki Yamawaki A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain Journal of Pharmacological Sciences |
| title | A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain |
| title_full | A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain |
| title_fullStr | A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain |
| title_full_unstemmed | A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain |
| title_short | A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain |
| title_sort | current perspective of canstatin a fragment of type iv collagen alpha 2 chain |
| url | http://www.sciencedirect.com/science/article/pii/S1347861318302202 |
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