Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study
Background Preserved ratio impaired spirometry (PRISm) is associated with increased cardiovascular disease (CVD) risk and mortality. However, a causal relationship between PRISm and CVD remains unclear. We investigated the progression of coronary artery calcium (CAC) scores based on the presence of...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2024-01-01
|
| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/1/00819-2023.full |
| _version_ | 1827330606515617792 |
|---|---|
| author | Yunjoo Im Hye Yun Park Jin-Young Lee Hyunsoo Kim Hongseok Yoo Mira Kang Soo Jin Cho Jung Hye Hwang Yong Bum Park Juhee Cho Danbee Kang Sun Hye Shin |
| author_facet | Yunjoo Im Hye Yun Park Jin-Young Lee Hyunsoo Kim Hongseok Yoo Mira Kang Soo Jin Cho Jung Hye Hwang Yong Bum Park Juhee Cho Danbee Kang Sun Hye Shin |
| author_sort | Yunjoo Im |
| collection | DOAJ |
| description | Background
Preserved ratio impaired spirometry (PRISm) is associated with increased cardiovascular disease (CVD) risk and mortality. However, a causal relationship between PRISm and CVD remains unclear. We investigated the progression of coronary artery calcium (CAC) scores based on the presence of PRISm and reduced forced vital capacity (FVC).
Methods
This retrospective cohort study included 11 420 participants aged ≥40 years with forced expiratory volume in 1 s (FEV1)/FVC ≥0.7 who underwent at least two health screening examinations with coronary computed tomography scan between 2003 and 2020, and were without a history of CVD or interstitial lung disease. Participants with PRISm, defined as FEV1/FVC ≥0.7 and FEV1 <80% predicted, were further divided by low FVC (FVC <80% predicted). We estimated the 5-year progression rates of CAC by comparing participants with and without PRISm at baseline using mixed linear models.
Results
Of the 11 420 participants, 8536 (75%), 811 (7%) and 2073 (18%) had normal spirometry, PRISm with normal FVC and PRISm with low FVC, respectively. During the mean (range) follow-up of 6.0 (0.5–17.2) years, the multivariable adjusted ratio of 5-year CAC progression rates comparing participants with PRISm to those with normal spirometry was 1.08 (95% CI 1.04–1.13). This rate was higher in participants with PRISm with low FVC (1.21 (95% CI 1.12–1.30)) than in those with normal FVC.
Conclusion
In this longitudinal cohort study of subjects without a history of CVD, PRISm was significantly associated with CAC progression, which was more evident in the group with PRISm and low FVC. |
| first_indexed | 2024-03-07T16:14:46Z |
| format | Article |
| id | doaj.art-2fcf2d8d0af64392b20a8f3569820ea3 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-07T16:14:46Z |
| publishDate | 2024-01-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-2fcf2d8d0af64392b20a8f3569820ea32024-03-04T11:30:00ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-01-0110110.1183/23120541.00819-202300819-2023Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort studyYunjoo Im0Hye Yun Park1Jin-Young Lee2Hyunsoo Kim3Hongseok Yoo4Mira Kang5Soo Jin Cho6Jung Hye Hwang7Yong Bum Park8Juhee Cho9Danbee Kang10Sun Hye Shin11 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Center for Clinical Epidemiology, Samsung Medical Center, Seoul, South Korea Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Department of Pulmonary and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea Center for Clinical Epidemiology, Samsung Medical Center, Seoul, South Korea Center for Clinical Epidemiology, Samsung Medical Center, Seoul, South Korea Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Background Preserved ratio impaired spirometry (PRISm) is associated with increased cardiovascular disease (CVD) risk and mortality. However, a causal relationship between PRISm and CVD remains unclear. We investigated the progression of coronary artery calcium (CAC) scores based on the presence of PRISm and reduced forced vital capacity (FVC). Methods This retrospective cohort study included 11 420 participants aged ≥40 years with forced expiratory volume in 1 s (FEV1)/FVC ≥0.7 who underwent at least two health screening examinations with coronary computed tomography scan between 2003 and 2020, and were without a history of CVD or interstitial lung disease. Participants with PRISm, defined as FEV1/FVC ≥0.7 and FEV1 <80% predicted, were further divided by low FVC (FVC <80% predicted). We estimated the 5-year progression rates of CAC by comparing participants with and without PRISm at baseline using mixed linear models. Results Of the 11 420 participants, 8536 (75%), 811 (7%) and 2073 (18%) had normal spirometry, PRISm with normal FVC and PRISm with low FVC, respectively. During the mean (range) follow-up of 6.0 (0.5–17.2) years, the multivariable adjusted ratio of 5-year CAC progression rates comparing participants with PRISm to those with normal spirometry was 1.08 (95% CI 1.04–1.13). This rate was higher in participants with PRISm with low FVC (1.21 (95% CI 1.12–1.30)) than in those with normal FVC. Conclusion In this longitudinal cohort study of subjects without a history of CVD, PRISm was significantly associated with CAC progression, which was more evident in the group with PRISm and low FVC.http://openres.ersjournals.com/content/10/1/00819-2023.full |
| spellingShingle | Yunjoo Im Hye Yun Park Jin-Young Lee Hyunsoo Kim Hongseok Yoo Mira Kang Soo Jin Cho Jung Hye Hwang Yong Bum Park Juhee Cho Danbee Kang Sun Hye Shin Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study ERJ Open Research |
| title | Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study |
| title_full | Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study |
| title_fullStr | Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study |
| title_full_unstemmed | Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study |
| title_short | Impact of preserved ratio impaired spirometry on coronary artery calcium score progression: a longitudinal cohort study |
| title_sort | impact of preserved ratio impaired spirometry on coronary artery calcium score progression a longitudinal cohort study |
| url | http://openres.ersjournals.com/content/10/1/00819-2023.full |
| work_keys_str_mv | AT yunjooim impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT hyeyunpark impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT jinyounglee impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT hyunsookim impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT hongseokyoo impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT mirakang impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT soojincho impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT junghyehwang impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT yongbumpark impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT juheecho impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT danbeekang impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy AT sunhyeshin impactofpreservedratioimpairedspirometryoncoronaryarterycalciumscoreprogressionalongitudinalcohortstudy |