Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects
Background: To determine the relationship between serum leptin and insulin resistance in obese Pakistani subjects. Methods: In this observational study fifty healthy obese and overweight subjects were selected by nonprobability convenience sampling. Age, sex, height, weight and body mass index (BMI)...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2012-12-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/557 |
| _version_ | 1811285485376503808 |
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| author | Ahsan Kazmi |
| author_facet | Ahsan Kazmi |
| author_sort | Ahsan Kazmi |
| collection | DOAJ |
| description | Background: To determine the relationship between
serum leptin and insulin resistance in obese Pakistani
subjects.
Methods: In this observational study fifty healthy
obese and overweight subjects were selected by nonprobability
convenience sampling. Age, sex, height,
weight and body mass index (BMI) of subjects were
recorded. Fasting plasma glucose, serum leptin and
insulin were measured. Fifty healthy non-obese subjects
served as control group.
Results: Serum leptin concentration was higher in
obese subjects (52.8 ± 24.6 ng/ml), with p value 0.001 than
in non-obese healthy controls (6.3 ± 3.1 ng/ml). Serum
leptin level was found higher in women (64.4ng/ml) than
in men (40.4ng/ml) only in obese group. Insulin resistance
was higher in obese subjects (11.1 ± 5.1), with p value 0.001
than control group (0.9 ± 0.4). BMI strongly correlated with
leptin concentration (r = 0.59 & p = 0.001) and insulin
resistance (r = 0.372 & p = 0.001) in obese group. There was
highly significant correlation between serum leptin
concentration and insulin resistance (r = 0.451 & p = 0.001)
in this group. In the control group, there was no
correlation between serum leptin concentration and
insulin resistance (r = 0.166 & p = 0.249).
Conclusions: Serum leptin is positively correlated
with insulin resistance in obese subjects. Serum leptin
level and insulin resistance are higher in obese subjects |
| first_indexed | 2024-04-13T02:45:37Z |
| format | Article |
| id | doaj.art-2fcf65b3227b447c83fbe9f771fdaf01 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-04-13T02:45:37Z |
| publishDate | 2012-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-2fcf65b3227b447c83fbe9f771fdaf012022-12-22T03:06:03ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702012-12-01162Assessment of Serum Leptin Level and Insulin Resistance in Obese SubjectsAhsan Kazmi0Department of Pathology, Rawalpindi Medical College,Rawalpindi;Background: To determine the relationship between serum leptin and insulin resistance in obese Pakistani subjects. Methods: In this observational study fifty healthy obese and overweight subjects were selected by nonprobability convenience sampling. Age, sex, height, weight and body mass index (BMI) of subjects were recorded. Fasting plasma glucose, serum leptin and insulin were measured. Fifty healthy non-obese subjects served as control group. Results: Serum leptin concentration was higher in obese subjects (52.8 ± 24.6 ng/ml), with p value 0.001 than in non-obese healthy controls (6.3 ± 3.1 ng/ml). Serum leptin level was found higher in women (64.4ng/ml) than in men (40.4ng/ml) only in obese group. Insulin resistance was higher in obese subjects (11.1 ± 5.1), with p value 0.001 than control group (0.9 ± 0.4). BMI strongly correlated with leptin concentration (r = 0.59 & p = 0.001) and insulin resistance (r = 0.372 & p = 0.001) in obese group. There was highly significant correlation between serum leptin concentration and insulin resistance (r = 0.451 & p = 0.001) in this group. In the control group, there was no correlation between serum leptin concentration and insulin resistance (r = 0.166 & p = 0.249). Conclusions: Serum leptin is positively correlated with insulin resistance in obese subjects. Serum leptin level and insulin resistance are higher in obese subjectshttps://www.journalrmc.com/index.php/JRMC/article/view/557Leptininsulin resistancebody mass indexobesity. |
| spellingShingle | Ahsan Kazmi Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects Journal of Rawalpindi Medical College Leptin insulin resistance body mass index obesity. |
| title | Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects |
| title_full | Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects |
| title_fullStr | Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects |
| title_full_unstemmed | Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects |
| title_short | Assessment of Serum Leptin Level and Insulin Resistance in Obese Subjects |
| title_sort | assessment of serum leptin level and insulin resistance in obese subjects |
| topic | Leptin insulin resistance body mass index obesity. |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/557 |
| work_keys_str_mv | AT ahsankazmi assessmentofserumleptinlevelandinsulinresistanceinobesesubjects |