Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study
Oral mucositis (OM) is a debilitating adverse event in patients undergoing treatment for cancer. This study aimed to evaluate the therapeutic effect of a novel handheld photobiomodulation therapy (PBMT) device on chemoradiation therapy (CRT)-induced OM in patients with head and neck cancer. Head and...
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MDPI AG
2023-02-01
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| 丛编: | Photonics |
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| 在线阅读: | https://www.mdpi.com/2304-6732/10/3/241 |
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| author | In-Young Jo Hyung-Kwon Byeon Myung-Jin Ban Jae-Hong Park Sang-Cheol Lee Yong Kyun Won Yun-Su Eun Jae-Yun Kim Na-Gyeong Yang Sul-Hee Lee Pyeongan Lee Nam-Hun Heo Sujin Jo Hoonhee Seo Sukyung Kim Ho-Yeon Song Jung-Eun Kim |
| author_facet | In-Young Jo Hyung-Kwon Byeon Myung-Jin Ban Jae-Hong Park Sang-Cheol Lee Yong Kyun Won Yun-Su Eun Jae-Yun Kim Na-Gyeong Yang Sul-Hee Lee Pyeongan Lee Nam-Hun Heo Sujin Jo Hoonhee Seo Sukyung Kim Ho-Yeon Song Jung-Eun Kim |
| author_sort | In-Young Jo |
| collection | DOAJ |
| description | Oral mucositis (OM) is a debilitating adverse event in patients undergoing treatment for cancer. This study aimed to evaluate the therapeutic effect of a novel handheld photobiomodulation therapy (PBMT) device on chemoradiation therapy (CRT)-induced OM in patients with head and neck cancer. Head and neck cancer patients undergoing CRT who developed moderate-to-severe OM during treatment were enrolled. After PBMT and at 2 and 4 weeks after PBMT, the mean value of OM grade decreased significantly from 2.63 to 2.13, 1.31, and 0.75, respectively (<i>p</i> < 0.05, <i>p</i> < 0.001, and <i>p</i> < 0.001). Moreover, we observed significant improvement in health-related quality of life (HRQoL) after PBMT compared to baseline through a validated questionnaire; EORTC QLQ-C30. In the present study, the use of this PBMT device in the management of CRT-induced OM in patients with head and neck cancer was generally well tolerated and resulted in the improvement of OM. However, evidence supporting its use remains lacking owing to limitations such as the small number of participants and lack of a control group. Therefore, further mechanistic studies and large-scale randomized controlled trials are needed to confirm the effectiveness of PBMT in the treatment of CRT-induced OM, as shown in our results. |
| first_indexed | 2024-03-11T06:00:58Z |
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| id | doaj.art-2fcfc1d625d64f3c8fc1ccecc053a176 |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-11T06:00:58Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-2fcfc1d625d64f3c8fc1ccecc053a1762023-11-17T13:18:16ZengMDPI AGPhotonics2304-67322023-02-0110324110.3390/photonics10030241Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series StudyIn-Young Jo0Hyung-Kwon Byeon1Myung-Jin Ban2Jae-Hong Park3Sang-Cheol Lee4Yong Kyun Won5Yun-Su Eun6Jae-Yun Kim7Na-Gyeong Yang8Sul-Hee Lee9Pyeongan Lee10Nam-Hun Heo11Sujin Jo12Hoonhee Seo13Sukyung Kim14Ho-Yeon Song15Jung-Eun Kim16Department of Radiation Oncology, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University Seoul Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul 04401, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDivision of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Radiation Oncology, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Dermatology, College of Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Dermatology, College of Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Dermatology, College of Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Dermatology, College of Medicine, Soonchunhyang University Bucheon Hospital, 170, Jomaru-ro, Bucheon-si 14584, Republic of KoreaDepartment of Dermatology, Soonchunhyang University Graduate School of Medicine, 22, Soonchunhyang-ro, Sinchang-myeon, Asan-si 31538, Republic of KoreaClinical Trial Center, College of Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaDepartment of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of KoreaDepartment of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of KoreaProbiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of KoreaDepartment of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of KoreaDepartment of Dermatology, College of Medicine, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Republic of KoreaOral mucositis (OM) is a debilitating adverse event in patients undergoing treatment for cancer. This study aimed to evaluate the therapeutic effect of a novel handheld photobiomodulation therapy (PBMT) device on chemoradiation therapy (CRT)-induced OM in patients with head and neck cancer. Head and neck cancer patients undergoing CRT who developed moderate-to-severe OM during treatment were enrolled. After PBMT and at 2 and 4 weeks after PBMT, the mean value of OM grade decreased significantly from 2.63 to 2.13, 1.31, and 0.75, respectively (<i>p</i> < 0.05, <i>p</i> < 0.001, and <i>p</i> < 0.001). Moreover, we observed significant improvement in health-related quality of life (HRQoL) after PBMT compared to baseline through a validated questionnaire; EORTC QLQ-C30. In the present study, the use of this PBMT device in the management of CRT-induced OM in patients with head and neck cancer was generally well tolerated and resulted in the improvement of OM. However, evidence supporting its use remains lacking owing to limitations such as the small number of participants and lack of a control group. Therefore, further mechanistic studies and large-scale randomized controlled trials are needed to confirm the effectiveness of PBMT in the treatment of CRT-induced OM, as shown in our results.https://www.mdpi.com/2304-6732/10/3/241photobiomodulationlow-level laser therapychemoradiation= therapyoral mucositishead and neck cancercase series |
| spellingShingle | In-Young Jo Hyung-Kwon Byeon Myung-Jin Ban Jae-Hong Park Sang-Cheol Lee Yong Kyun Won Yun-Su Eun Jae-Yun Kim Na-Gyeong Yang Sul-Hee Lee Pyeongan Lee Nam-Hun Heo Sujin Jo Hoonhee Seo Sukyung Kim Ho-Yeon Song Jung-Eun Kim Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study Photonics photobiomodulation low-level laser therapy chemoradiation= therapy oral mucositis head and neck cancer case series |
| title | Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study |
| title_full | Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study |
| title_fullStr | Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study |
| title_full_unstemmed | Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study |
| title_short | Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study |
| title_sort | effect of a novel handheld photobiomodulation therapy device in the management of chemoradiation therapy induced oral mucositis in head and neck cancer patients a case series study |
| topic | photobiomodulation low-level laser therapy chemoradiation= therapy oral mucositis head and neck cancer case series |
| url | https://www.mdpi.com/2304-6732/10/3/241 |
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