Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
Acute myeloid leukemia (AML) is one of the malignant hematological cancers with high mortality. Finding a more effective and readily available treatment is of the utmost importance. Here, we aimed to identify the anti-leukemia effect of a natural small molecule compound honokiol on a panel of AML ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.897791/full |
| _version_ | 1818241111530930176 |
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| author | Xingrong Lai Xingrong Lai Yanhua Sun Xuedi Zhang Xuedi Zhang Dan Wang Jialing Wang Jialing Wang Haihua Wang Haihua Wang Yao Zhao Yao Zhao Xinling Liu Xinling Liu Xin Xu Xin Xu Haoran Song Wenjia Ping Yanli Sun Yanli Sun Zhenbo Hu Zhenbo Hu |
| author_facet | Xingrong Lai Xingrong Lai Yanhua Sun Xuedi Zhang Xuedi Zhang Dan Wang Jialing Wang Jialing Wang Haihua Wang Haihua Wang Yao Zhao Yao Zhao Xinling Liu Xinling Liu Xin Xu Xin Xu Haoran Song Wenjia Ping Yanli Sun Yanli Sun Zhenbo Hu Zhenbo Hu |
| author_sort | Xingrong Lai |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is one of the malignant hematological cancers with high mortality. Finding a more effective and readily available treatment is of the utmost importance. Here, we aimed to identify the anti-leukemia effect of a natural small molecule compound honokiol on a panel of AML cell lines, including THP-1, U-937, and SKM-1, and explored honokiol’s potential biological pathways and mechanisms. The results showed that honokiol decreased the viability of the targeted AML cells, induced their cell cycle arrest at G0/G1 phase, and inhibited their colony-formation capacity. Honokiol also triggers a noncanonical ferroptosis pathway in THP-1 and U-937 cells by upregulating the level of intracellular lipid peroxide and HMOX1 significantly. Subsequent studies verified that HMOX1 was a critical target in honokiol-induced ferroptosis. These results reveal that honokiol is an effective anti-leukemia agent in AML cell lines and may be a potential ferroptosis activator in AML. |
| first_indexed | 2024-12-12T13:24:09Z |
| format | Article |
| id | doaj.art-2fd0199c87204c26a6ef6471630b4a27 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T13:24:09Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2fd0199c87204c26a6ef6471630b4a272022-12-22T00:23:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.897791897791Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia CellsXingrong Lai0Xingrong Lai1Yanhua Sun2Xuedi Zhang3Xuedi Zhang4Dan Wang5Jialing Wang6Jialing Wang7Haihua Wang8Haihua Wang9Yao Zhao10Yao Zhao11Xinling Liu12Xinling Liu13Xin Xu14Xin Xu15Haoran Song16Wenjia Ping17Yanli Sun18Yanli Sun19Zhenbo Hu20Zhenbo Hu21Laboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaWeifang Medical University, Weifang, ChinaDepartment of Hematology, Weifang People’s Hospital, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaWeifang Medical University, Weifang, ChinaWeifang Medical University, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaWeifang Medical University, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaSchool of Life Science and Technology, Weifang Medical University, Weifang, ChinaDepartment of Laboratory Medicine, Weifang Medical University, Weifang, ChinaDepartment of Laboratory Medicine, Weifang Medical University, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Laboratory Medicine, Weifang Medical University, Weifang, ChinaLaboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaAcute myeloid leukemia (AML) is one of the malignant hematological cancers with high mortality. Finding a more effective and readily available treatment is of the utmost importance. Here, we aimed to identify the anti-leukemia effect of a natural small molecule compound honokiol on a panel of AML cell lines, including THP-1, U-937, and SKM-1, and explored honokiol’s potential biological pathways and mechanisms. The results showed that honokiol decreased the viability of the targeted AML cells, induced their cell cycle arrest at G0/G1 phase, and inhibited their colony-formation capacity. Honokiol also triggers a noncanonical ferroptosis pathway in THP-1 and U-937 cells by upregulating the level of intracellular lipid peroxide and HMOX1 significantly. Subsequent studies verified that HMOX1 was a critical target in honokiol-induced ferroptosis. These results reveal that honokiol is an effective anti-leukemia agent in AML cell lines and may be a potential ferroptosis activator in AML.https://www.frontiersin.org/articles/10.3389/fphar.2022.897791/fullhonokiolAMLferroptosisheme oxygenase (HO)-1lipid peroxidation |
| spellingShingle | Xingrong Lai Xingrong Lai Yanhua Sun Xuedi Zhang Xuedi Zhang Dan Wang Jialing Wang Jialing Wang Haihua Wang Haihua Wang Yao Zhao Yao Zhao Xinling Liu Xinling Liu Xin Xu Xin Xu Haoran Song Wenjia Ping Yanli Sun Yanli Sun Zhenbo Hu Zhenbo Hu Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells Frontiers in Pharmacology honokiol AML ferroptosis heme oxygenase (HO)-1 lipid peroxidation |
| title | Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells |
| title_full | Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells |
| title_fullStr | Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells |
| title_full_unstemmed | Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells |
| title_short | Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells |
| title_sort | honokiol induces ferroptosis by upregulating hmox1 in acute myeloid leukemia cells |
| topic | honokiol AML ferroptosis heme oxygenase (HO)-1 lipid peroxidation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.897791/full |
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