Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B
We report the case of a 19-year-old male with possible cerebral mucormycosis following chemotherapy. We detected a Lichtheimia DNA load of 2.0 × 104 copies/ml in cerebrospinal fluid (CSF), although a CSF culture showed no growth. After treatment with intravenous liposomal amphotericin B, the Lichthe...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971214016750 |
| _version_ | 1819033795768090624 |
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| author | Tomonari Shigemura Yozo Nakazawa Kazuyuki Matsuda Mitsuo Motobayashi Shoji Saito Kenichi Koike |
| author_facet | Tomonari Shigemura Yozo Nakazawa Kazuyuki Matsuda Mitsuo Motobayashi Shoji Saito Kenichi Koike |
| author_sort | Tomonari Shigemura |
| collection | DOAJ |
| description | We report the case of a 19-year-old male with possible cerebral mucormycosis following chemotherapy. We detected a Lichtheimia DNA load of 2.0 × 104 copies/ml in cerebrospinal fluid (CSF), although a CSF culture showed no growth. After treatment with intravenous liposomal amphotericin B, the Lichtheimia DNA load fell below the detection limit, and at the same time the patient's headache and imaging findings improved. The quantification of Mucorales DNA in CSF may be useful for evaluating cerebral mucormycosis. |
| first_indexed | 2024-12-21T07:23:31Z |
| format | Article |
| id | doaj.art-2fd061cef3f14b42ad31936df8456fad |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-21T07:23:31Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-2fd061cef3f14b42ad31936df8456fad2022-12-21T19:11:44ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112014-12-0129C20020210.1016/j.ijid.2014.10.019Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin BTomonari Shigemura0Yozo Nakazawa1Kazuyuki Matsuda2Mitsuo Motobayashi3Shoji Saito4Kenichi Koike5Department of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, JapanDepartment of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, JapanDepartment of Laboratory Medicine, Shinshu University Hospital, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, JapanDepartment of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, JapanDepartment of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, JapanWe report the case of a 19-year-old male with possible cerebral mucormycosis following chemotherapy. We detected a Lichtheimia DNA load of 2.0 × 104 copies/ml in cerebrospinal fluid (CSF), although a CSF culture showed no growth. After treatment with intravenous liposomal amphotericin B, the Lichtheimia DNA load fell below the detection limit, and at the same time the patient's headache and imaging findings improved. The quantification of Mucorales DNA in CSF may be useful for evaluating cerebral mucormycosis.http://www.sciencedirect.com/science/article/pii/S1201971214016750MucormycosisLichtheimiaCerebrospinal fluidQuantitative PCRLiposomal amphotericin B |
| spellingShingle | Tomonari Shigemura Yozo Nakazawa Kazuyuki Matsuda Mitsuo Motobayashi Shoji Saito Kenichi Koike Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B International Journal of Infectious Diseases Mucormycosis Lichtheimia Cerebrospinal fluid Quantitative PCR Liposomal amphotericin B |
| title | Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B |
| title_full | Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B |
| title_fullStr | Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B |
| title_full_unstemmed | Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B |
| title_short | Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B |
| title_sort | evaluation of mucorales dna load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin b |
| topic | Mucormycosis Lichtheimia Cerebrospinal fluid Quantitative PCR Liposomal amphotericin B |
| url | http://www.sciencedirect.com/science/article/pii/S1201971214016750 |
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