Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels
Endothelial lipase (LIPG) and zinc finger protein 202 (ZNF202) are two pivotal genes in HDL metabolism, and therefore, it is important to understand the impact their sequence variants may have on HDL cholesterol levels. We resequenced the entire both genes in White and Hispanic individuals having hi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00089/full |
| _version_ | 1818845010992300032 |
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| author | Hamid eRazzaghi Stephanie A Santorico M Ilyas Kamboh |
| author_facet | Hamid eRazzaghi Stephanie A Santorico M Ilyas Kamboh |
| author_sort | Hamid eRazzaghi |
| collection | DOAJ |
| description | Endothelial lipase (LIPG) and zinc finger protein 202 (ZNF202) are two pivotal genes in HDL metabolism, and therefore, it is important to understand the impact their sequence variants may have on HDL cholesterol levels. We resequenced the entire both genes in White and Hispanic individuals having high ( =75.90 mg/dl, n=114) or low ( =31.24 mg/dl, n=121) HDL cholesterol levels, and identified a total of 185 and 122 sequence variants in LIPG and ZNF202, respectively. We found only two missense variants in LIPG (T111I and N396S) and two in ZNF202 (A154V and K259E). In both genes, there were several rare variants unique to either the low or high HDL group. For LIPG, the proportion of unique variants differed between the high and low HDL groups in both Whites (p=0.022) and Hispanics (p=0.017), but for ZNF202 this difference was observed only in Hispanics (p=0.021). We also identified a common haplotype in ZNF202 among Whites that was significantly associated with high HDL group (p=0.0133). These findings provide insights into the genetics of LIPG and ZNF202, and suggest that sequence variants occurring with high frequency in non-exonic regions may play a prominent role in modulating HDL-C levels in the general population. |
| first_indexed | 2024-12-19T05:22:52Z |
| format | Article |
| id | doaj.art-2fd0e5af60a54c08bdad71ca6b42bf08 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-19T05:22:52Z |
| publishDate | 2012-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj.art-2fd0e5af60a54c08bdad71ca6b42bf082022-12-21T20:34:27ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-06-01310.3389/fgene.2012.0008924104Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL LevelsHamid eRazzaghi0Stephanie A Santorico1M Ilyas Kamboh2University of Colorado DenverUniversity of Colorado DenverUniversity of PittsburghEndothelial lipase (LIPG) and zinc finger protein 202 (ZNF202) are two pivotal genes in HDL metabolism, and therefore, it is important to understand the impact their sequence variants may have on HDL cholesterol levels. We resequenced the entire both genes in White and Hispanic individuals having high ( =75.90 mg/dl, n=114) or low ( =31.24 mg/dl, n=121) HDL cholesterol levels, and identified a total of 185 and 122 sequence variants in LIPG and ZNF202, respectively. We found only two missense variants in LIPG (T111I and N396S) and two in ZNF202 (A154V and K259E). In both genes, there were several rare variants unique to either the low or high HDL group. For LIPG, the proportion of unique variants differed between the high and low HDL groups in both Whites (p=0.022) and Hispanics (p=0.017), but for ZNF202 this difference was observed only in Hispanics (p=0.021). We also identified a common haplotype in ZNF202 among Whites that was significantly associated with high HDL group (p=0.0133). These findings provide insights into the genetics of LIPG and ZNF202, and suggest that sequence variants occurring with high frequency in non-exonic regions may play a prominent role in modulating HDL-C levels in the general population.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00089/fullLIPGZNF202Endothelial lipaseZinc Finger Protein 202HDLGenetic association |
| spellingShingle | Hamid eRazzaghi Stephanie A Santorico M Ilyas Kamboh Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels Frontiers in Genetics LIPG ZNF202 Endothelial lipase Zinc Finger Protein 202 HDL Genetic association |
| title | Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels |
| title_full | Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels |
| title_fullStr | Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels |
| title_full_unstemmed | Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels |
| title_short | Population-based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels |
| title_sort | population based resequencing of lipg and znf202 genes in subjects with extreme hdl levels |
| topic | LIPG ZNF202 Endothelial lipase Zinc Finger Protein 202 HDL Genetic association |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00089/full |
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