Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids Assessed Using a Design of Experiment Protocol

Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids Assessed Using a Design of Experiment Protocol

Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which can cause bioavailability and bioequivalence issues. This stu...

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Bibliographic Details
Main Authors:	Bayan E. Ainousah, Ibrahim Khadra, Gavin W. Halbert
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	Pharmaceutics
Subjects:	fenofibrate mannitol polyvinylpyrrolidone hydroxypropylmethylcellulose chitosan simulated fasted intestinal media
Online Access:	https://www.mdpi.com/1999-4923/15/10/2484

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