Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population
Oxidative stress is closely related to the occurrence and development of various diseases such as cancer, diabetes, and cardiovascular and infectious diseases. We identified six critical genetic variants related to oxidative stress, and evaluated their main effects and their interaction effects on h...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-01-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2019.01290/full |
| _version_ | 1811269730781102080 |
|---|---|
| author | Ning Ma Wenxuan Liu Xiaolin Zhang Xia Gao Fengxue Yu Weiheng Guo Yanxin Meng Ping Gao Jin Zhou Meina Yuan Yingjun Mi Lei Zhang Sufen Qi Lu Li Luyao Wang Qiao Su Lei Yang Dianwu Liu |
| author_facet | Ning Ma Wenxuan Liu Xiaolin Zhang Xia Gao Fengxue Yu Weiheng Guo Yanxin Meng Ping Gao Jin Zhou Meina Yuan Yingjun Mi Lei Zhang Sufen Qi Lu Li Luyao Wang Qiao Su Lei Yang Dianwu Liu |
| author_sort | Ning Ma |
| collection | DOAJ |
| description | Oxidative stress is closely related to the occurrence and development of various diseases such as cancer, diabetes, and cardiovascular and infectious diseases. We identified six critical genetic variants related to oxidative stress, and evaluated their main effects and their interaction effects on hepatitis B virus (HBV)-induced liver diseases. We enrolled 3,128 Han Chinese subjects into five groups: healthy controls, chronic hepatitis B (CHB), liver cirrhosis (LC), hepatocellular carcinoma (HCC), and natural clearance. We then determined the genotypes in each group for CYBA-rs4673, NCF4-rs1883112, NOX4-rs1836882, rs3017887, SOD2-rs4880, and GCLM-rs41303970, and evaluated the association between these variants and HBV-induced liver diseases. Gene-gene interactions were evaluated using generalized multifactor dimensionality reduction, logistic regression, and four-by-two tables. Significant associations were observed between healthy controls and the CIB group (CHB+LC+HCC). The CYBA-rs4673AG genotype was associated with a 1.356 rate of susceptibility of HBV-induced liver disease compared to the wild type GG genotype. The NCF4-rs1883112G allele occurred more frequently in healthy controls than in the CIB group in all three models (dominant, codominant, and recessive). Nox4-rs1836882 TC showed a protective association, being more frequent in healthy controls compared to the wild type TT genotype. GCLM-rs41303970A was associated with HBV-induced liver disease. The overall best model by multifactor dimensionality reduction was a five factor interaction model that had the highest cross validation consistency (10/10) and test accuracy (0.5669), P= 0.001. Oxidative stress-related gene polymorphisms are likely to be associated with HBV-induced liver disease, suggesting that information on these variations is useful for risk assessment of HBV-induced liver disease. |
| first_indexed | 2024-04-12T21:48:27Z |
| format | Article |
| id | doaj.art-2fd3ea8bf5b347dfa559bbe983e7278a |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T21:48:27Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-2fd3ea8bf5b347dfa559bbe983e7278a2022-12-22T03:15:34ZengFrontiers Media S.A.Frontiers in Genetics1664-80212020-01-011010.3389/fgene.2019.01290472674Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han PopulationNing Ma0Wenxuan Liu1Xiaolin Zhang2Xia Gao3Fengxue Yu4Weiheng Guo5Yanxin Meng6Ping Gao7Jin Zhou8Meina Yuan9Yingjun Mi10Lei Zhang11Sufen Qi12Lu Li13Luyao Wang14Qiao Su15Lei Yang16Dianwu Liu17Hebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaThe Hebei Key Laboratory of Gastroenterology, Division of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaAntenatal Diagnosis Center, The Fourth Hospital of Shijiazhuang, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaSchool of Basic Medicine, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaHebei Key Laboratory of Environment and Human Health, Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaOxidative stress is closely related to the occurrence and development of various diseases such as cancer, diabetes, and cardiovascular and infectious diseases. We identified six critical genetic variants related to oxidative stress, and evaluated their main effects and their interaction effects on hepatitis B virus (HBV)-induced liver diseases. We enrolled 3,128 Han Chinese subjects into five groups: healthy controls, chronic hepatitis B (CHB), liver cirrhosis (LC), hepatocellular carcinoma (HCC), and natural clearance. We then determined the genotypes in each group for CYBA-rs4673, NCF4-rs1883112, NOX4-rs1836882, rs3017887, SOD2-rs4880, and GCLM-rs41303970, and evaluated the association between these variants and HBV-induced liver diseases. Gene-gene interactions were evaluated using generalized multifactor dimensionality reduction, logistic regression, and four-by-two tables. Significant associations were observed between healthy controls and the CIB group (CHB+LC+HCC). The CYBA-rs4673AG genotype was associated with a 1.356 rate of susceptibility of HBV-induced liver disease compared to the wild type GG genotype. The NCF4-rs1883112G allele occurred more frequently in healthy controls than in the CIB group in all three models (dominant, codominant, and recessive). Nox4-rs1836882 TC showed a protective association, being more frequent in healthy controls compared to the wild type TT genotype. GCLM-rs41303970A was associated with HBV-induced liver disease. The overall best model by multifactor dimensionality reduction was a five factor interaction model that had the highest cross validation consistency (10/10) and test accuracy (0.5669), P= 0.001. Oxidative stress-related gene polymorphisms are likely to be associated with HBV-induced liver disease, suggesting that information on these variations is useful for risk assessment of HBV-induced liver disease.https://www.frontiersin.org/article/10.3389/fgene.2019.01290/fullgene polymorphismshepatitis B virusoxidative stressCYBANCF4Nox4 |
| spellingShingle | Ning Ma Wenxuan Liu Xiaolin Zhang Xia Gao Fengxue Yu Weiheng Guo Yanxin Meng Ping Gao Jin Zhou Meina Yuan Yingjun Mi Lei Zhang Sufen Qi Lu Li Luyao Wang Qiao Su Lei Yang Dianwu Liu Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population Frontiers in Genetics gene polymorphisms hepatitis B virus oxidative stress CYBA NCF4 Nox4 |
| title | Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population |
| title_full | Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population |
| title_fullStr | Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population |
| title_full_unstemmed | Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population |
| title_short | Oxidative Stress-Related Gene Polymorphisms Are Associated With Hepatitis B Virus-Induced Liver Disease in the Northern Chinese Han Population |
| title_sort | oxidative stress related gene polymorphisms are associated with hepatitis b virus induced liver disease in the northern chinese han population |
| topic | gene polymorphisms hepatitis B virus oxidative stress CYBA NCF4 Nox4 |
| url | https://www.frontiersin.org/article/10.3389/fgene.2019.01290/full |
| work_keys_str_mv | AT ningma oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT wenxuanliu oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT xiaolinzhang oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT xiagao oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT fengxueyu oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT weihengguo oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT yanxinmeng oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT pinggao oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT jinzhou oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT meinayuan oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT yingjunmi oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT leizhang oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT sufenqi oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT luli oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT luyaowang oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT qiaosu oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT leiyang oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation AT dianwuliu oxidativestressrelatedgenepolymorphismsareassociatedwithhepatitisbvirusinducedliverdiseaseinthenorthernchinesehanpopulation |