Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Abstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) fo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
2019-05-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100656&lng=en&tlng=en |
| _version_ | 1811255834548633600 |
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| author | Wanting Wu Yuan Liang Guangchao Wu Yinghang Su Hongying Zhang Zhenyan Zhang Changsheng Deng Qi Wang Bo Huang Bo Tan Chongjun Zhou Jianping Song |
| author_facet | Wanting Wu Yuan Liang Guangchao Wu Yinghang Su Hongying Zhang Zhenyan Zhang Changsheng Deng Qi Wang Bo Huang Bo Tan Chongjun Zhou Jianping Song |
| author_sort | Wanting Wu |
| collection | DOAJ |
| description | Abstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria. METHODS: This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study. RESULTS: Some cases of QT prolongation were observed. However, no TdP was found. CONCLUSIONS: AP may cause QT interval prolongation in some malaria patients but may not lead to TdP. |
| first_indexed | 2024-04-12T17:30:54Z |
| format | Article |
| id | doaj.art-2fd4a0d399d04cb188d5f9d0f537066b |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T17:30:54Z |
| publishDate | 2019-05-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-2fd4a0d399d04cb188d5f9d0f537066b2022-12-22T03:23:08ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492019-05-0152010.1590/0037-8682-0453-2018S0037-86822019000100656Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patientsWanting WuYuan LiangGuangchao WuYinghang SuHongying ZhangZhenyan ZhangChangsheng DengQi WangBo HuangBo TanChongjun ZhouJianping SongAbstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria. METHODS: This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study. RESULTS: Some cases of QT prolongation were observed. However, no TdP was found. CONCLUSIONS: AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100656&lng=en&tlng=enECGQTArtemisinin-piperaquineMalariaCambodia |
| spellingShingle | Wanting Wu Yuan Liang Guangchao Wu Yinghang Su Hongying Zhang Zhenyan Zhang Changsheng Deng Qi Wang Bo Huang Bo Tan Chongjun Zhou Jianping Song Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients Revista da Sociedade Brasileira de Medicina Tropical ECG QT Artemisinin-piperaquine Malaria Cambodia |
| title | Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients |
| title_full | Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients |
| title_fullStr | Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients |
| title_full_unstemmed | Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients |
| title_short | Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients |
| title_sort | effect of artemisinin piperaquine treatment on the electrocardiogram of malaria patients |
| topic | ECG QT Artemisinin-piperaquine Malaria Cambodia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100656&lng=en&tlng=en |
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