“All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based Vaccines
It has been 50 years since Peter Charles Doherty and Rolf M Zinkernagel proposed the principle of “simultaneous dual recognition”, according to which adaptive immune cells recognized “self” and “non-self” simultaneously to establish immunological efficacy. These two scientists shared the 1996 Nobel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/1/72 |
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| author | Laura Padula Eva Fisher Natasa Strbo |
| author_facet | Laura Padula Eva Fisher Natasa Strbo |
| author_sort | Laura Padula |
| collection | DOAJ |
| description | It has been 50 years since Peter Charles Doherty and Rolf M Zinkernagel proposed the principle of “simultaneous dual recognition”, according to which adaptive immune cells recognized “self” and “non-self” simultaneously to establish immunological efficacy. These two scientists shared the 1996 Nobel Prize in Physiology or Medicine for this discovery. Their basic immunological principle became the foundation for the development of numerous vaccine approaches against infectious diseases and tumors, including promising strategies grounded on the use of recombinant gp96-Ig developed by our lab over the last two decades. In this review, we will highlight three major principles of the gp96-Ig vaccine strategy: (1) presentation of pathogenic antigens to T cells (specificity); (2) activation of innate immune responses (adjuvanticity); (3) priming of T cells to home to the epithelial compartments (mucosal immunity). In summary, we provide a paradigm for a vaccine approach that can be rapidly engineered and customized for any future pathogens that require induction of effective tissue-resident memory responses in epithelial tissues. |
| first_indexed | 2024-03-08T15:09:10Z |
| format | Article |
| id | doaj.art-2fd635b980d34be0b7b132a8267a0dcd |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T15:09:10Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2fd635b980d34be0b7b132a8267a0dcd2024-01-10T14:53:25ZengMDPI AGCells2073-44092023-12-011317210.3390/cells13010072“All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based VaccinesLaura Padula0Eva Fisher1Natasa Strbo2Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USADepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USADepartment of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USAIt has been 50 years since Peter Charles Doherty and Rolf M Zinkernagel proposed the principle of “simultaneous dual recognition”, according to which adaptive immune cells recognized “self” and “non-self” simultaneously to establish immunological efficacy. These two scientists shared the 1996 Nobel Prize in Physiology or Medicine for this discovery. Their basic immunological principle became the foundation for the development of numerous vaccine approaches against infectious diseases and tumors, including promising strategies grounded on the use of recombinant gp96-Ig developed by our lab over the last two decades. In this review, we will highlight three major principles of the gp96-Ig vaccine strategy: (1) presentation of pathogenic antigens to T cells (specificity); (2) activation of innate immune responses (adjuvanticity); (3) priming of T cells to home to the epithelial compartments (mucosal immunity). In summary, we provide a paradigm for a vaccine approach that can be rapidly engineered and customized for any future pathogens that require induction of effective tissue-resident memory responses in epithelial tissues.https://www.mdpi.com/2073-4409/13/1/72heat shock proteinsgp96vaccineantigen cross presentationmucosal immunityinnate and adaptive immune responses |
| spellingShingle | Laura Padula Eva Fisher Natasa Strbo “All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based Vaccines Cells heat shock proteins gp96 vaccine antigen cross presentation mucosal immunity innate and adaptive immune responses |
| title | “All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based Vaccines |
| title_full | “All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based Vaccines |
| title_fullStr | “All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based Vaccines |
| title_full_unstemmed | “All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based Vaccines |
| title_short | “All for One and One for All”: The Secreted Heat Shock Protein gp96-Ig Based Vaccines |
| title_sort | all for one and one for all the secreted heat shock protein gp96 ig based vaccines |
| topic | heat shock proteins gp96 vaccine antigen cross presentation mucosal immunity innate and adaptive immune responses |
| url | https://www.mdpi.com/2073-4409/13/1/72 |
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