REST promotes ETS1‐dependent vascular growth in medulloblastoma

REST promotes ETS1‐dependent vascular growth in medulloblastoma

Expression of the RE1‐silencing transcription factor (REST), a master regulator of neurogenesis, is elevated in medulloblastoma (MB) tumors. A cell‐intrinsic function for REST in MB tumorigenesis is known. However, a role for REST in the regulation of MB tumor microenvironment has not been investiga...

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Bibliographic Details
Main Authors: Shavali Shaik, Shinji Maegawa, Amanda R Haltom, Feng Wang, Xue Xiao, Tara Dobson, Ajay Sharma, Yanwen Yang, Jyothishmathi Swaminathan, Vikas Kundra, Xiao Nan Li, Keri Schadler, Arif Harmanci, Lin Xu, Vidya Gopalakrishnan
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Molecular Oncology
Subjects:
medulloblastoma
REST
NRSF
tumor microenvironment
vasculature
Online Access:https://doi.org/10.1002/1878-0261.12903

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